Protein Domain : IPR011992

Type:  Domain Name:  EF-hand domain pair
Description:  This domain consists of a duplication of two EF-hand units, where each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain [, ]. These include: calbindin D9K, S100 proteins such as calcyclin, polcalcin phl p 7 (a calcium-binding pollen allergen), osteonectin, parvalbumin, calmodulin [] family of proteins (troponin C, caltractin, cdc4p, myosin essential chain, calcineurin, recoverin, neurocalcin), plasmodial-specific CaII-binding protein Cbp40, penta-EF-Hand proteins [] (sorcin, grancalcin, calpain), as well as multidomain proteins such as phosphoinositide-specific phospholipase C, dystrophin, Cb1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins. Short Name:  EF-hand-dom_pair
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3 Child Features

DB identifier Type Name
IPR015359 Domain Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR019577 Domain SPARC/Testican, calcium-binding domain
IPR014741 Domain Adaptor protein Cbl, EF hand-like

11 Contains

DB identifier Type Name
IPR002048 Domain EF-hand domain
IPR013623 Domain NADPH oxidase Respiratory burst
IPR013567 Domain EF hand associated, type-2
IPR013566 Domain EF hand associated, type-1
IPR013787 Domain S100/CaBP-9k-type, calcium binding, subdomain
IPR018247 Binding_site EF-Hand 1, calcium-binding site
IPR015153 Domain EF-hand domain, type 1
IPR015154 Domain EF-hand domain, type 2
IPR001999 Conserved_site Osteonectin-like, conserved site
IPR014837 Domain EF-hand, Ca insensitive
IPR001751 Conserved_site S100/Calbindin-D9k, conserved site

2 Cross Referencess

Identifier
PF13499
G3DSA:1.10.238.10

10 Found Ins

DB identifier Type Name
IPR001217 Family Transcription factor STAT
IPR008080 Family Parvalbumin
IPR013333 Family Ryanodine receptor
IPR016344 Family Dystrophin
IPR016359 Family SPARC-like protein 1
IPR015754 Family Calcium binding protein 2
IPR015756 Family Guanylate cyclase activating protein 2
IPR015757 Family Calcineurin B protein
IPR013801 Domain STAT transcription factor, DNA-binding
IPR017432 Family Distrobrevin

0 GO Annotation

0 Ontology Annotations

0 Parent Features

70408 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92726 D8RF67 PAC:15420653 Selaginella moellendorffii 504  
231573 D8RGN7 PAC:15417617 Selaginella moellendorffii 411  
93701 D8RHI5 PAC:15423431 Selaginella moellendorffii 380  
411403 D8RHT6 PAC:15408444 Selaginella moellendorffii 188  
95926 D8RKN2 PAC:15408570 Selaginella moellendorffii 145  
96034 D8RKR2 PAC:15404581 Selaginella moellendorffii 496  
172574 D8RL71 PAC:15412721 Selaginella moellendorffii 157  
412625 D8RM37 PAC:15413072 Selaginella moellendorffii 183  
412739 D8RLB5 PAC:15413937 Selaginella moellendorffii 813  
59528 D8RLC2 PAC:15410857 Selaginella moellendorffii 121  
96597 D8RL53 PAC:15408604 Selaginella moellendorffii 159  
404706 D8QW55 PAC:15412423 Selaginella moellendorffii 594  
69135 D8QVQ2 PAC:15415017 Selaginella moellendorffii 140  
17501 D8RPL0 PAC:15420743 Selaginella moellendorffii 147  
173046 D8RNW1 PAC:15411778 Selaginella moellendorffii 452  
270984 D8RNL6 PAC:15401901 Selaginella moellendorffii 180  
413463 D8RPJ4 PAC:15414617 Selaginella moellendorffii 163  
148957 D8RQ38 PAC:15411715 Selaginella moellendorffii 470  
173355 D8RQC7 PAC:15414147 Selaginella moellendorffii 640  
413855 D8RQF4 PAC:15417554 Selaginella moellendorffii 169  
413868 D8RQH1 PAC:15417579 Selaginella moellendorffii 465  
99178 PAC:15414412 Selaginella moellendorffii 494  
99105 PAC:15414254 Selaginella moellendorffii 331  
173444 D8RR32 PAC:15414880 Selaginella moellendorffii 579  
413960 D8RR65 PAC:15418347 Selaginella moellendorffii 208  
52345 D8RTD9 PAC:15411238 Selaginella moellendorffii 525  
36610 D8RV92 PAC:15410752 Selaginella moellendorffii 170  
415389 PAC:15419647 Selaginella moellendorffii 1988  
141966 D8QWY9 PAC:15413595 Selaginella moellendorffii 149  
404785 D8QXC4 PAC:15412608 Selaginella moellendorffii 592  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12111723
            11114499
            12445459
            12542690