| Type: | Family | Name: | Ryanodine receptor |
| Description: | Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteinsfunction as a Ca2+-release channels following depolarisation of transverse-tubules []. The function is modulated by Ca2+, Mg2+, ATP and calmodulin. Deficiency in the ryanodine receptor may be the cause of malignanthyperthermia (MH) and of central core disease of muscle (CCD) []. MH isan autosomal dominant disorder of skeletal muscle and is a principal cause of death due to anaesthesia.Calcium release activity of the receptors resides in the C-terminal region of the protein, the remaining part of the molecule forming a 'foot'structure that spans the junctional gap between the sarcoplamic reticulum and the transverse-tubule. The foot structure may interact with thecytoplasmic region of the dihydropyridine receptor.Analysis of the sequence reveals 10 potential transmembrane (TM) regions in the C-terminal fifth of the molecule and 2 further potential TM regionsnearer to the centre []. These may contribute to the formation of the Ca2+conducting pore. The rest of the sequence is hydrophilic, and presumably constitutes the cytoplasmic domain of the protein. | Short Name: | Ryan_recept |
| DB identifier | Type | Name |
|---|---|---|
| IPR016093 | Domain | MIR motif |
| IPR011992 | Domain | EF-hand domain pair |
| IPR005821 | Domain | Ion transport domain |
| IPR001870 | Domain | B30.2/SPRY domain |
| IPR003877 | Domain | SPRY domain |
| IPR000699 | Domain | RIH (RyR and IP3R Homology) domain |
| IPR014821 | Domain | Inositol 1,4,5-trisphosphate/ryanodine receptor |
| IPR013662 | Domain | RyR/IP3R Homology associated domain |
| IPR009460 | Domain | Ryanodine Receptor TM 4-6 |
| IPR003032 | Domain | Ryanodine receptor Ryr |
