Protein Domain : IPR015925

Type:  Family Name:  Ryanodine receptor-related
Description:  The ryanodine and inositol 1,4,5-triphosphate (IP3) receptors are intracellular Ca2+ release channels characterised by their large size and 4-fold symmetry []. In excitation-contraction coupling of skeletal and heart muscle, the ryanodine receptor serves as a Ca2+ release channel of sarcoplasmic reticulum (SR) and is morphologically identical to the foot structure spanning the gap between terminal cisternae of SR and sarcolemma/transverse tubules. The IP3receptor acts as a Ca2+ release channel of non-mitochondrial intracellular Ca2+ stores in smooth muscle and in non-muscle tissues.The so-called excitation-contraction coupling phenomenon in muscle cells takes place in a highly specialised junctional region that arise from close proximity between plasma membrane (PM) and SR. More precisely, transverse tubular invaginations of the PM touch the terminal cisternae of SR to form a unique anatomical structure known as the triad junction [, , ]. In skeletal muscle, dihydropyridine receptors (DHPRs) located in the transverse tubule membrane function mainly as the voltage sensor which sends an orthograde signal to control opening of the ryanodine receptor/Ca2+ release channel [, ]. There appears to a physical interaction between DHPRs and ryanodine receptors in the triad junction without requiring the movement of extracellular Ca2+ through DHPRs in the PM [].IP3 receptors are large (~1200 kDa) tetrameric proteins, each subunit of which projects an amino-terminal domain into the cytoplasm, their membrane-spanning carboxy-terminal regions forming an integral Ca2+ channel. IP3binding by the amino-terminal domains causes a conformational change that promotes channel opening. Between the IP3binding site and the transmembrane regions is a large stretch of amino acids where a significant proportion of regulatory interactions occur. Although IP3 is necessary to open native IP3 receptors, activation of these channels is complex and their open probability actually depends on the ambient Ca2+ concentration. Up to ~ 500 nM, Ca2+ works synergistically with IP3to activate IP3receptors. At higher concentrations, cytosolic Ca2+ inhibits IP3receptor opening. The inhibition of IP3receptors by Ca2+ is thought to be a crucial mechanism for terminating channel activity and thus preventing pathological Ca2+ rises. Short Name:  Ryanodine_recept-rel
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2 Child Features

DB identifier Type Name
IPR013333 Family Ryanodine receptor
IPR000493 Family Inositol 1,4,5-trisphosphate-binding protein receptor

7 Contains

DB identifier Type Name
IPR016093 Domain MIR motif
IPR005821 Domain Ion transport domain
IPR000699 Domain RIH (RyR and IP3R Homology) domain
IPR014821 Domain Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR013662 Domain RyR/IP3R Homology associated domain
IPR009460 Domain Ryanodine Receptor TM 4-6
IPR003032 Domain Ryanodine receptor Ryr

1 Cross References

Identifier
PTHR13715

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre16.g665450.t1.1 A0A2K3CTW4 PAC:30777802 Chlamydomonas reinhardtii 3210  
Vocar.0066s0001.1.p PAC:32891742 Volvox carteri 977  
Vocar.0090s0011.1.p PAC:32884102 Volvox carteri 746  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2660829
            12765683
            8010750
            1426638
            1562172
            1648106
            2455801