Protein Domain : IPR000493

Type:  Family Name:  Inositol 1,4,5-trisphosphate-binding protein receptor
Description:  Inositol 1,4,5-trisphosphate (InsP3) is an intracellular second messenger that transduces growth factor and neurotransmitter signals. InsP3 mediatesthe release of Ca2+from intracellular stores by binding to specific Ca2+channel-coupled receptors. One such receptor contains a C-terminal Ca2+channel with 8 possible transmembrane (TM) regions, while its N-terminal cytoplasmic region houses ligand-binding and modulatory sites [, ]. Ca2+appears to inhibit ligand binding, possibly by interacting with a Ca2+-binding protein that itself inhibits the receptor.The InsP3 receptor is an integral membrane protein located in the endoplasmic reticulum. It is a homotetramer. The protein shows somesimilarity to the ryanodine receptor, which functions as a Ca2+-release channel in the sarcoplasmic reticulum of cardiac and skeletal muscle []. Short Name:  InsP3_rcpt-bd
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0 Child Features

5 Contains

DB identifier Type Name
IPR016093 Domain MIR motif
IPR005821 Domain Ion transport domain
IPR000699 Domain RIH (RyR and IP3R Homology) domain
IPR014821 Domain Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR013662 Domain RyR/IP3R Homology associated domain

1 Cross References

Identifier
PR00779

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005220 IPR000493
GO:0006816 IPR000493
GO:0005783 IPR000493
GO:0016020 IPR000493

4 Ontology Annotations

GO Term Gene Name
GO:0005220 IPR000493
GO:0006816 IPR000493
GO:0005783 IPR000493
GO:0016020 IPR000493

1 Parent Features

DB identifier Type Name
IPR015925 Family Ryanodine receptor-related

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1655411
            2165071
            1645727