| Type: | Domain | Name: | EF-hand domain |
| Description: | Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type ofdomain consists of a twelve residue loop flanked on both sides by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion iscoordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residuesare denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). | Short Name: | EF_hand_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR011992 | Domain | EF-hand domain pair |
| IPR000261 | Domain | EH domain |
| IPR021181 | Family | Mitochondrial Rho GTPase |
| IPR003299 | Family | Flagellar calcium-binding protein calflagin |
| IPR008080 | Family | Parvalbumin |
| IPR012008 | Family | Serine/threonine-protein phosphatase with EF-hands |
| IPR015754 | Family | Calcium binding protein 2 |
| IPR015756 | Family | Guanylate cyclase activating protein 2 |
| IPR015757 | Family | Calcineurin B protein |
