Protein Domain : IPR012008

Type:  Family Name:  Serine/threonine-protein phosphatase with EF-hands
Description:  This well-conserved family of animal EF-hand-containing serine/threonine protein phosphatases functions in diverse sensory neurons. The protein comprises an IQ calmodulin-binding region, a metallo-phosphoesterase domain () of the serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase type, and a C-terminal extension with three calcium-binding EF-hand motifs.The prototype protein is the product of the fruit fly rdgC gene, which is required to prevent light-induced retinal degeneration []. There are two homologous mammalian genes, PPEF1 and PPEF2. Although no essential role has been identified, PPEF2 is expressed in retinal rod photoreceptors, where it assumes several splice forms, and in the pineal gland. PPEF1 is expressed in photosensory neurons and inner ear cells in the developing mouse []. Short Name:  Ser/Thr-Pase_EF-hand_contain
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0 Child Features

5 Contains

DB identifier Type Name
IPR013235 Domain PPP domain
IPR002048 Domain EF-hand domain
IPR000048 Binding_site IQ motif, EF-hand binding site
IPR006186 Domain Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR018247 Binding_site EF-Hand 1, calcium-binding site

1 Cross References

Identifier
PIRSF000912

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004721 IPR012008
GO:0005506 IPR012008
GO:0005509 IPR012008
GO:0030145 IPR012008
GO:0050906 IPR012008

5 Ontology Annotations

GO Term Gene Name
GO:0004721 IPR012008
GO:0005506 IPR012008
GO:0005509 IPR012008
GO:0030145 IPR012008
GO:0050906 IPR012008

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9326663
            1316807