Protein Domain : IPR018247

Type:  Binding_site Name:  EF-Hand 1, calcium-binding site
Description:  Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type ofdomain consists of a twelve residue loop flanked on both sides by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion iscoordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residuesare denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).This signature pattern includes the complete EF-hand loop as well as the first residue which follows the loop and which seem to always be hydrophobic. Note: positions 1 (X), 3 (Y) and 12 (-Z) are the most conserved. The 6th residue in an EF-hand loop is, in most cases a Gly, but the number of exceptions to this 'rule' has gradually increased, therefore, this signature pattern includes all the different residues which have been shown to exist in this position in functional Ca-binding sites. The pattern is known, in some cases, to miss one of the EF-hand regions in some proteins with multiple EF-hand domains. Short Name:  EF_Hand_1_Ca_BS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00018

18 Found Ins

DB identifier Type Name
IPR016688 Family Mechanosensitive ion channel MscS-like, plants/fungi
IPR011992 Domain EF-hand domain pair
IPR000261 Domain EH domain
IPR021181 Family Mitochondrial Rho GTPase
IPR019577 Domain SPARC/Testican, calcium-binding domain
IPR016134 Domain Cellulosome enzyme, dockerin type I
IPR003299 Family Flagellar calcium-binding protein calflagin
IPR008080 Family Parvalbumin
IPR002105 Repeat Cellulosome enzyme, dockerin type I, calcium-binding motif
IPR016359 Family SPARC-like protein 1
IPR016279 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR012008 Family Serine/threonine-protein phosphatase with EF-hands
IPR015754 Family Calcium binding protein 2
IPR015756 Family Guanylate cyclase activating protein 2
IPR015757 Family Calcineurin B protein
IPR009208 Family Mosquitocidal toxin
IPR012045 Family Peptidase M6, unassigned InhA-related
IPR001751 Conserved_site S100/Calbindin-D9k, conserved site

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

0 Publications