Protein Domain : IPR019577

Type:  Domain Name:  SPARC/Testican, calcium-binding domain
Description:  This entry represents the calcium-binding domain found in SPARC (Secreted Protein Acidic and Rich in Cysteine) and Testican (also known as SPOCK; or SParc/Osteonectin, Cwcv and Kazal-like domains) proteins. SPARC proteins are down-regulated in various tumours and may have a tumour-suppressor function [, ]. Testican-3 appears to be a novel regulator that reduces the activity of matrix metalloproteinase (MMP) in adult T-cell leukemia (ATL) [].This cysteine-rich domain is responsible for the anti-spreading activity of human urothelial cells. This extracellular calcium-binding domain is rich in alpha-helices and contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2 []. Short Name:  SPARC/Testican_Ca-bd-dom
Paste the following link

0 Child Features

2 Contains

DB identifier Type Name
IPR018247 Binding_site EF-Hand 1, calcium-binding site
IPR001999 Conserved_site Osteonectin-like, conserved site

1 Cross References

Identifier
PF10591

1 Found In

DB identifier Type Name
IPR016359 Family SPARC-like protein 1

3 GO Annotations

GO Term Gene Name
GO:0005509 IPR019577
GO:0007165 IPR019577
GO:0005578 IPR019577

3 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR019577
GO:0007165 IPR019577
GO:0005578 IPR019577

1 Parent Features

DB identifier Type Name
IPR011992 Domain EF-hand domain pair

203 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cucsa.032300.1 PAC:16952430 Cucumis sativus 320  
Thhalv10025621m V4P4U8 PAC:20194546 Eutrema salsugineum 346  
Araha.1893s0005.1.p PAC:28846055 Arabidopsis halleri 345  
Cagra.1225s0115.1.p PAC:28904079 Capsella grandiflora 346  
Glyma.19G067200.1.p K7MX34 PAC:30515206 Glycine max 349  
Bostr.7867s0608.1.p PAC:30658768 Boechera stricta 354  
Medtr2g078340.1 A0A072V9A7 PAC:31066189 Medicago truncatula 413  
Medtr8g020310.2 G7L6S1 PAC:31070642 Medicago truncatula 287  
Medtr8g020310.1 G7L6S1 PAC:31070641 Medicago truncatula 287  
Sphfalx0127s0021.1.p PAC:32621788 Sphagnum fallax 410  
Bradi3g08370.1.p I1HYU8 PAC:32823174 Brachypodium distachyon 377  
Aqcoe7G006100.1.p A0A2G5DZG5 PAC:33073455 Aquilegia coerulea 348  
Brdisv1Per11025035m.p PAC:33211219 Brachypodium distachyon Per1 379  
Brdisv1Per11025037m.p PAC:33211220 Brachypodium distachyon Per1 379  
Brdisv1Per11025036m.p PAC:33211221 Brachypodium distachyon Per1 379  
Brdisv1Uni21030332m.p PAC:33287764 Brachypodium distachyon Uni2 379  
Brdisv1Uni21030330m.p PAC:33287765 Brachypodium distachyon Uni2 379  
Brdisv1Uni21030331m.p PAC:33287763 Brachypodium distachyon Uni2 379  
Brdisv1BdTR7a1032014m.p PAC:33368426 Brachypodium distachyon BdTR7a 377  
Brdisv1Koz-11032413m.p I1HYU8 PAC:33419690 Brachypodium distachyon Koz-1 377  
Brdisv20Bd21Ref1026419m.p I1HYU8 PAC:33471058 Brachypodium distachyon Bd21 AnntCtrl 377  
Brdisv20Bd21Ref1026420m.p I1HYU8 PAC:33471059 Brachypodium distachyon Bd21 AnntCtrl 377  
Brdisv20Bd21Ref1026421m.p I1HYU8 PAC:33471060 Brachypodium distachyon Bd21 AnntCtrl 377  
Brdisv1Tek-41016854m.p PAC:33513130 Brachypodium distachyon Tek-4 377  
Brdisv1Tek-41016853m.p PAC:33513129 Brachypodium distachyon Tek-4 377  
Brdisv1ABR9_r1024970m.p PAC:33541460 Brachypodium distachyon ABR9 377  
Brdisv1BdTR13a1033636m.p PAC:33591139 Brachypodium distachyon BdTR13a 377  
Brdisv1BdTR13a1033635m.p PAC:33591140 Brachypodium distachyon BdTR13a 377  
Brdisv1pangenome1039648m.p I1HYU8 PAC:33632304 Brachypodium distachyon Pangenome 377  
Brdisv1pangenome1039649m.p I1HYU8 PAC:33632302 Brachypodium distachyon Pangenome 377  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17325739
            16121393
            18459035
            19144404