Type: | Conserved_site | Name: | Osteonectin-like, conserved site |
Description: | The osteonectin like domain, of unknown function, is found in extracellular proteins strongly expressed in tissues undergoing morphogenesis. It is a 240 amino acids domain, highly conserved, localized in the C-terminal part of the protein [].This domain has a N-terminal section of about 90 residues that contains 11 conserved cysteines, a central section that is probably in an alpha-helical conformation, and a C-terminal section that contains two EF-hand type calcium-binding regions [] and three conserved cysteines. This topology is schematically represented below.+----+ | |xCxCxCxxCCxCxxxCxxCxCxxxxxCxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx(Ca)xCxxC(Ca)Cxx C: conserved cysteines involved in disulphide bonds. Ca: EF-hand region see(). | Short Name: | Osteonectin_CS |