Protein Domain : IPR016279

Type:  Family Name:  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
Description:  This group represents a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma. Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets. Short Name:  PLC-gamma
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2 Child Features

DB identifier Type Name
IPR028380 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
IPR028381 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

10 Contains

DB identifier Type Name
IPR000008 Domain C2 domain
IPR001452 Domain SH3 domain
IPR011993 Domain Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
IPR001849 Domain Pleckstrin homology domain
IPR017946 Domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR000909 Domain Phosphatidylinositol-specific phospholipase C, X domain
IPR015359 Domain Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR001711 Domain Phospholipase C, phosphatidylinositol-specific, Y domain
IPR000980 Domain SH2 domain
IPR018247 Binding_site EF-Hand 1, calcium-binding site

1 Cross References

Identifier
PIRSF000952

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004435 IPR016279
GO:0004871 IPR016279
GO:0007165 IPR016279
GO:0009395 IPR016279

4 Ontology Annotations

GO Term Gene Name
GO:0004435 IPR016279
GO:0004871 IPR016279
GO:0007165 IPR016279
GO:0009395 IPR016279

1 Parent Features

DB identifier Type Name
IPR001192 Family Phosphoinositide phospholipase C family

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11602179
            20807769