Protein Domain : IPR001711

Type:  Domain Name:  Phospholipase C, phosphatidylinositol-specific, Y domain
Description:  Phosphatidylinositol-specific phospholipase C (), an eukaryotic intracellular enzyme, plays an important role in signal transduction processes [] (see ). It catalyzes the hydrolysis of 1-phosphatidyl-D-myo-inositol-3,4,5-triphosphate into the second messenger molecules diacylglycerol and inositol-1,4,5-triphosphate. This catalytic process is tightly regulated by reversible phosphorylation and binding of regulatory proteins [, , ].In mammals, there are at least 6 different isoforms of PI-PLC, they differ in their domain structure, their regulation, and their tissue distribution. Lower eukaryotes also possess multiple isoforms of PI-PLC.All eukaryotic PI-PLCs contain two regions of homology, sometimes referred to as 'X-box' (see ) and 'Y-box'. The order of these two regions is always the same (NH2-X-Y-COOH), but the spacing is variable. In most isoforms, the distance between these two regions is only 50-100 residues but in the gamma isoforms one PH domain, two SH2 domains, and one SH3 domain are inserted between the two PLC-specific domains. The two conserved regions have been shown to be important for the catalytic activity. At the C-terminal of the Y-box, there is a C2 domain (see ) possibly involved in Ca-dependent membrane attachment. Short Name:  PLipase_C_Pinositol-sp_Y
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF00387
PS50008
SM00149

4 Found Ins

DB identifier Type Name
IPR017946 Domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Family Phosphoinositide phospholipase C family
IPR016280 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR016279 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma

4 GO Annotations

GO Term Gene Name
GO:0004435 IPR001711
GO:0006629 IPR001711
GO:0007165 IPR001711
GO:0035556 IPR001711

4 Ontology Annotations

GO Term Gene Name
GO:0004435 IPR001711
GO:0006629 IPR001711
GO:0007165 IPR001711
GO:0035556 IPR001711

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109775 D8S698 PAC:15406585 Selaginella moellendorffii 523  
75628 D8QNU3 PAC:15414347 Selaginella moellendorffii 588  
evm.model.supercontig_112.10 PAC:16405908 Carica papaya 575  
evm.model.supercontig_112.23 PAC:16405922 Carica papaya 591  
evm.model.supercontig_112.16 PAC:16405914 Carica papaya 199  
evm.model.supercontig_112.22 PAC:16405921 Carica papaya 425  
evm.model.supercontig_112.21 PAC:16405920 Carica papaya 191  
evm.model.supercontig_19.174 PAC:16411910 Carica papaya 1028  
30111.m000700 B9SK18 PAC:16817859 Ricinus communis 551  
29681.m001356 B9SI34 PAC:16805642 Ricinus communis 563  
29681.m001355 B9SI33 PAC:16805641 Ricinus communis 578  
29681.m001354 B9SI32 PAC:16805640 Ricinus communis 578  
28833.m000159 B9T5Y1 PAC:16801773 Ricinus communis 594  
28833.m000158 B9T5Y0 PAC:16801772 Ricinus communis 601  
Cucsa.368570.1 A0A0A0KSE1 PAC:16981691 Cucumis sativus 599  
Cucsa.368570.2 PAC:16981692 Cucumis sativus 429  
Cucsa.136660.1 A0A0A0KAC7 PAC:16963148 Cucumis sativus 586  
Cucsa.147070.1 A0A0A0LVI7 PAC:16964016 Cucumis sativus 572  
Cucsa.147070.2 PAC:16964017 Cucumis sativus 461  
orange1.1g007734m A0A067G0H2 PAC:18138224 Citrus sinensis 591  
orange1.1g007399m A0A067FZT1 PAC:18138223 Citrus sinensis 605  
orange1.1g008582m A0A067FS12 PAC:18138225 Citrus sinensis 561  
orange1.1g010960m A0A067FNI0 PAC:18138226 Citrus sinensis 496  
orange1.1g017257m A0A067FNK7 PAC:18138228 Citrus sinensis 374  
orange1.1g007473m A0A067FUL6 PAC:18111411 Citrus sinensis 602  
orange1.1g010810m A0A067FTW9 PAC:18111412 Citrus sinensis 500  
orange1.1g013747m A0A067FHQ7 PAC:18111413 Citrus sinensis 437  
orange1.1g007887m A0A067FHL9 PAC:18111576 Citrus sinensis 586  
orange1.1g011026m A0A067FL82 PAC:18111577 Citrus sinensis 495  
orange1.1g042071m A0A067EGL4 PAC:18115901 Citrus sinensis 632  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1419362
            1849017
            1319994
            1335185