Protein Domain : IPR001192

Type:  Family Name:  Phosphoinositide phospholipase C family
Description:  This entry represents phosphoinositol-specific phospholipase C (PLC) from eukaryotes. Proteins in this entry include PLC-beta, gamma, delta, epsilon, eta, zeta and inactive phospholipase C-like protein 2 (PLC-L2). Phosphoinositol-specific phospholipase C (PLC; () plays an important role in signal transduction processes [], mediating the cellular actions of a variety of hormones, neurotransmitters and growth factors. Upon agonist-dependent activation, PLC catalyses the hydrolysis of membrane phosphatidylinositol 4,5-bisphosphate (PIP2), generating the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 binds specific intracellular receptors to trigger Ca2+mobilisation, while DAG mediates activation of a family of protein kinase C isozymes. This catalytic process is tightly regulated by reversible phosphorylation and binding of regulatory proteins [, , ]. Based on molecular size, immunoreactivity and amino acid sequence, several subtypes have been classified. Overall, sequence identity between sub-types is low, yet all isoforms share a split TIM barrel containing two conserved domains, designated X and Y []. The core eukaryotic PLC enzyme is composed of a pleckstrin homology (PH) domain, four tandem EF hand domains, a split TIM barrel, and a C2 domain []. The presence of an insert in the TIM barrel led to the naming of the N- and C-terminal halves of the TIM barrel as 'X-box' and 'Y-box'. The order of these two regions is always the same (NH2-X-Y-COOH), but the spacing is variable. In most isoforms, the distance between these two regions is only 50-100 residues, for example, in PLC-beta subtypes, X and Y domains are separated by a stretch of 70-120 amino acids rich in Ser, Thr and acidic residues (their C terminus is rich in basic residues). However, in PLC-gammas, there is an insert of more than 400 residues containing a PH domain, two SH2 domains, and one SH3 domain. The two conserved X and Y domains have been shown to be important for the catalytic activity. C-terminal to the Y-box, there is a C2 domain, possibly involved in Ca-dependent membrane attachment. Short Name:  PI-PLC_fam
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12 Child Features

DB identifier Type Name
IPR016280 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR016279 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR028395 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
IPR028398 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
IPR028391 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
IPR028392 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
IPR028393 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
IPR028387 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
IPR028382 Family Inactive phospholipase C-like protein 1
IPR028383 Family Inactive phospholipase C-like protein 2
IPR028406 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
IPR028407 Family Phospholipase C, Plc21C

5 Contains

DB identifier Type Name
IPR000008 Domain C2 domain
IPR017946 Domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR000909 Domain Phosphatidylinositol-specific phospholipase C, X domain
IPR015359 Domain Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR001711 Domain Phospholipase C, phosphatidylinositol-specific, Y domain

2 Cross Referencess

Identifier
PTHR10336
PR00390

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0035556 IPR001192

1 Ontology Annotations

GO Term Gene Name
GO:0035556 IPR001192

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
109775 D8S698 PAC:15406585 Selaginella moellendorffii 523  
75628 D8QNU3 PAC:15414347 Selaginella moellendorffii 588  
evm.model.supercontig_112.10 PAC:16405908 Carica papaya 575  
evm.model.supercontig_112.11 PAC:16405909 Carica papaya 122  
evm.model.supercontig_112.23 PAC:16405922 Carica papaya 591  
evm.model.supercontig_112.14 PAC:16405912 Carica papaya 380  
evm.model.supercontig_112.16 PAC:16405914 Carica papaya 199  
evm.model.supercontig_112.19 PAC:16405917 Carica papaya 198  
evm.model.supercontig_112.22 PAC:16405921 Carica papaya 425  
evm.model.supercontig_112.20 PAC:16405919 Carica papaya 129  
evm.model.supercontig_112.21 PAC:16405920 Carica papaya 191  
evm.model.supercontig_19.174 PAC:16411910 Carica papaya 1028  
30111.m000700 B9SK18 PAC:16817859 Ricinus communis 551  
29681.m001356 B9SI34 PAC:16805642 Ricinus communis 563  
29681.m001355 B9SI33 PAC:16805641 Ricinus communis 578  
29681.m001354 B9SI32 PAC:16805640 Ricinus communis 578  
28833.m000159 B9T5Y1 PAC:16801773 Ricinus communis 594  
28833.m000158 B9T5Y0 PAC:16801772 Ricinus communis 601  
Cucsa.368570.1 A0A0A0KSE1 PAC:16981691 Cucumis sativus 599  
Cucsa.368570.2 PAC:16981692 Cucumis sativus 429  
Cucsa.136660.1 A0A0A0KAC7 PAC:16963148 Cucumis sativus 586  
Cucsa.147070.1 A0A0A0LVI7 PAC:16964016 Cucumis sativus 572  
Cucsa.147070.2 PAC:16964017 Cucumis sativus 461  
orange1.1g043888m A0A067G0H6 PAC:18137978 Citrus sinensis 372  
orange1.1g007734m A0A067G0H2 PAC:18138224 Citrus sinensis 591  
orange1.1g007399m A0A067FZT1 PAC:18138223 Citrus sinensis 605  
orange1.1g008582m A0A067FS12 PAC:18138225 Citrus sinensis 561  
orange1.1g010960m A0A067FNI0 PAC:18138226 Citrus sinensis 496  
orange1.1g017257m A0A067FNK7 PAC:18138228 Citrus sinensis 374  
orange1.1g015698m A0A067FS17 PAC:18138227 Citrus sinensis 402  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1319994
            1335185
            9062102
            9048554
            23140367