| Type: | Family | Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
| Description: | Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [, ].Phospholipase C delta-4 overexpression upregulates the Erk signaling pathway and proliferation []. It is required for acrosome reaction in sperm during fertilisation, probably by acting as an important enzyme for intracellular Ca2+ mobilisation in the zona pellucida-induced acrosome reaction [, ]. It modulates the liver regeneration in cooperation with nuclear PKC []. | Short Name: | PLC-delta4 |
| GO Term | Gene Name |
|---|---|
| GO:0004629 | IPR028387 |
| GO:0007165 | IPR028387 |
| GO:0007340 | IPR028387 |
| GO:0046488 | IPR028387 |
| GO:0005622 | IPR028387 |
| GO Term | Gene Name |
|---|---|
| GO:0004629 | IPR028387 |
| GO:0007165 | IPR028387 |
| GO:0007340 | IPR028387 |
| GO:0046488 | IPR028387 |
| GO:0005622 | IPR028387 |
