Protein Domain : IPR016280

Type:  Family Name:  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
Description:  This group represents phospholipase C-beta, also known as 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta. PLC-beta isoforms mediate the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) to propagate signals for several physiological responses [, ]. This entry also includes NorpA, a phospholipase C (PLC) from Drosophila expressed in the eye. NorpA is a essential component of the phototransduction pathway in Drosophila []. Short Name:  PLC-beta
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3 Child Features

DB identifier Type Name
IPR028390 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
IPR028400 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
IPR028403 Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

7 Contains

DB identifier Type Name
IPR000008 Domain C2 domain
IPR017946 Domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR000909 Domain Phosphatidylinositol-specific phospholipase C, X domain
IPR015359 Domain Phosphoinositide-specific phospholipase C, EF-hand-like domain
IPR001711 Domain Phospholipase C, phosphatidylinositol-specific, Y domain
IPR014815 Domain Phospholipase C-beta, C-terminal domain
IPR009535 Conserved_site Phospholipase C-beta, conserved site

1 Cross References

Identifier
PIRSF000956

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004435 IPR016280
GO:0005509 IPR016280

2 Ontology Annotations

GO Term Gene Name
GO:0004435 IPR016280
GO:0005509 IPR016280

1 Parent Features

DB identifier Type Name
IPR001192 Family Phosphoinositide phospholipase C family

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11118617
            2457447
            25193662