Protein Domain : IPR017946

Type:  Domain Name:  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
Description:  This entry represents a structural domain consisting of a TIM beta/alpha-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including:Mammalian phospholipase C isozyme D1 [].Bacterial phosphatidylinositol-specific phospholipase C [].Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coliand UgpQ from Agrobacterium tumefaciens[].Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades []. Short Name:  PLC-like_Pdiesterase_TIM-brl
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1 Child Features

DB identifier Type Name
IPR030395 Domain Glycerophosphodiester phosphodiesterase domain

3 Contains

DB identifier Type Name
IPR000909 Domain Phosphatidylinositol-specific phospholipase C, X domain
IPR001711 Domain Phospholipase C, phosphatidylinositol-specific, Y domain
IPR003633 Domain Phospholipase C, variant-surface-glycoprotein

2 Cross Referencess

Identifier
G3DSA:3.20.20.190
SSF51695

4 Found Ins

DB identifier Type Name
IPR001192 Family Phosphoinositide phospholipase C family
IPR004129 Family Glycerophosphoryl diester phosphodiesterase
IPR016280 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR016279 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma

2 GO Annotations

GO Term Gene Name
GO:0008081 IPR017946
GO:0006629 IPR017946

2 Ontology Annotations

GO Term Gene Name
GO:0008081 IPR017946
GO:0006629 IPR017946

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
100702 D8RRS4 PAC:15402428 Selaginella moellendorffii 707  
443348 D8S0L9 PAC:15412997 Selaginella moellendorffii 340  
109775 D8S698 PAC:15406585 Selaginella moellendorffii 523  
233224 D8S6M9 PAC:15420977 Selaginella moellendorffii 314  
25432 D8QZL1 PAC:15421306 Selaginella moellendorffii 236  
82124 D8R081 PAC:15408823 Selaginella moellendorffii 320  
167542 D8R307 PAC:15420054 Selaginella moellendorffii 366  
85502 D8R6K5 PAC:15420640 Selaginella moellendorffii 366  
130410 D8T2B6 PAC:15421695 Selaginella moellendorffii 361  
74684 D8QPK8 PAC:15411527 Selaginella moellendorffii 321  
75628 D8QNU3 PAC:15414347 Selaginella moellendorffii 588  
evm.TU.contig_38432.1 PAC:16431187 Carica papaya 176  
evm.model.supercontig_1.154 PAC:16404071 Carica papaya 364  
evm.model.supercontig_1086.2 PAC:16405516 Carica papaya 396  
evm.model.supercontig_112.10 PAC:16405908 Carica papaya 575  
evm.model.supercontig_112.11 PAC:16405909 Carica papaya 122  
evm.model.supercontig_112.23 PAC:16405922 Carica papaya 591  
evm.model.supercontig_112.14 PAC:16405912 Carica papaya 380  
evm.model.supercontig_112.16 PAC:16405914 Carica papaya 199  
evm.model.supercontig_112.19 PAC:16405917 Carica papaya 198  
evm.model.supercontig_112.22 PAC:16405921 Carica papaya 425  
evm.model.supercontig_112.21 PAC:16405920 Carica papaya 191  
evm.model.supercontig_12.218 PAC:16406768 Carica papaya 496  
evm.model.supercontig_12.217 PAC:16406767 Carica papaya 300  
evm.model.supercontig_12.219 PAC:16406769 Carica papaya 742  
evm.model.supercontig_14.208 PAC:16408712 Carica papaya 416  
evm.model.supercontig_142.7 PAC:16408992 Carica papaya 274  
evm.model.supercontig_1524.2 PAC:16409665 Carica papaya 147  
evm.model.supercontig_1524.3 PAC:16409666 Carica papaya 161  
evm.model.supercontig_19.174 PAC:16411910 Carica papaya 1028  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8784353
            9335537
            16909422
            18691970