Protein Domain : IPR000008

Type:  Domain Name:  C2 domain
Description:  The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes, including phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies of the C1 domain in Protein Kinase C (that bind phorbol esters and diacylglycerol) (see ) and the protein kinase catalytic domain (see ). Regions with significant homology [] to the C2-domain have been found in many proteins.The C2 domain is thought to be involved in calcium-dependent phospholipid binding [] and in membrane targetting processes such as subcellular localisation. The 3D structure of the C2 domain of synaptotagmin has been reported[], the domain forms an eight-stranded beta sandwich constructed around a conserved 4-stranded motif, designated a C2 key []. Calcium binds ina cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel beta sandwich. Short Name:  C2_dom
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2 Child Features

DB identifier Type Name
IPR014020 Domain Tensin phosphatase, C2 domain
IPR002420 Domain Phosphatidylinositol 3-kinase, C2 domain

1 Contains

DB identifier Type Name
IPR001565 Domain Synaptotagmin

6 Cross Referencess

Identifier
PF00168
PR00360
PS50004
SM00239
G3DSA:2.60.40.150
SSF49562

11 Found Ins

DB identifier Type Name
IPR001192 Family Phosphoinositide phospholipase C family
IPR011402 Family Phospholipase D, plant
IPR015427 Family Synaptotagmin 7
IPR016280 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR016279 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR014375 Family Protein kinase C, alpha/beta/gamma types
IPR014376 Family Protein kinase C, delta/epsilon/eta/theta types
IPR014705 Family Synaptotagmin-17
IPR017147 Family Tricalbin
IPR014638 Family Double C2 protein, alpha/beta/gamma
IPR015428 Family Synaptotagmin 1

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR000008

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR000008

0 Parent Features

38556 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410613 D8RFA6 PAC:15407024 Selaginella moellendorffii 1812  
171388 D8RGQ7 PAC:15408186 Selaginella moellendorffii 751  
411129 D8RGN5 PAC:15406231 Selaginella moellendorffii 269  
441151 D8RGY3 PAC:15405547 Selaginella moellendorffii 270  
93870 D8RGN6 PAC:15402124 Selaginella moellendorffii 1002  
441825 D8RMV6 PAC:15410958 Selaginella moellendorffii 801  
97360 D8RMQ9 PAC:15410005 Selaginella moellendorffii 803  
97299 D8RMW4 PAC:15409302 Selaginella moellendorffii 124  
78846 D8QW39 PAC:15402275 Selaginella moellendorffii 2105  
148785 D8RPH2 PAC:15410258 Selaginella moellendorffii 137  
101052 D8RTB3 PAC:15422411 Selaginella moellendorffii 466  
32229 PAC:15418313 Selaginella moellendorffii 355  
165923 D8QXW1 PAC:15417215 Selaginella moellendorffii 804  
405179 D8QWH5 PAC:15410943 Selaginella moellendorffii 736  
438370 D8QXG0 PAC:15420471 Selaginella moellendorffii 575  
438513 D8QWG2 PAC:15421744 Selaginella moellendorffii 543  
61934 PAC:15420011 Selaginella moellendorffii 388  
416325 D8RYX7 PAC:15422330 Selaginella moellendorffii 201  
443351 D8S0M5 PAC:15413028 Selaginella moellendorffii 301  
443644 D8S365 PAC:15415323 Selaginella moellendorffii 260  
108987 D8S5B1 PAC:15405212 Selaginella moellendorffii 133  
109775 D8S698 PAC:15406585 Selaginella moellendorffii 523  
406042 D8R0H1 PAC:15413004 Selaginella moellendorffii 174  
81096 PAC:15405273 Selaginella moellendorffii 559  
82084 D8QZ93 PAC:15408149 Selaginella moellendorffii 810  
444195 D8S7R7 PAC:15414574 Selaginella moellendorffii 549  
153581 D8S963 PAC:15423478 Selaginella moellendorffii 834  
420891 D8SDG1 PAC:15416099 Selaginella moellendorffii 214  
178863 D8SDF9 PAC:15410245 Selaginella moellendorffii 1914  
421109 D8SE66 PAC:15413480 Selaginella moellendorffii 217  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7697723
            8253763
            7559667