Protein Domain : IPR014020

Type:  Domain Name:  Tensin phosphatase, C2 domain
Description:  Tensins constitute an eukaryotic family of lipid phosphatases that are defined by the presence of two adjacent domains: a lipid phosphatase domain and a C2-like domain. The tensin-type C2 domain has a structure similar to the classical C2 domain (see ) that mediates the Ca2+-dependent membrane recruitment of several signalling proteins. However the tensin-type C2 domain lacks two of the three conserved loops that bind Ca2+, and in this respect it is similar to the C2 domains of PKC-type [, ]. The tensin-type C2 domain can bind phopholipid membranes in a Ca2+ independent manner []. In the tumour suppressor protein PTEN, the best characterised member of the family, the lipid phosphatase domain was shown to specifically dephosphorylate the D3 position of the inositol ring of the lipid second messenger, phosphatydilinositol-3-4-5-triphosphate (PIP3). The lipid phosphatase domain contains the signature motif HCXXGXXR present in the active sites of protein tyrosine phosphatases (PTPs) and dual specificity phosphatases (DSPs). Furthermore, two invariant lysines are found only in the tensin-type phosphatase motif (HCKXGKXR) and are suspected to interact with the phosphate group at position D1 and D5 of the inositol ring [, ]. The C2 domain is found at the C terminus of the tumour suppressor protein PTEN (phosphatidyl-inositol triphosphate phosphatase). This domain may include a CBR3 loop, indicating a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc suggesting that the C2 domain productively positions the catalytic part of the protein on the membrane. The crystal structure of the PTEN tumour suppressor has been solved []. The lipid phosphatase domain has a structure similar to the dual specificity phosphatase (see ). However, PTEN has a larger active site pocket that could be important to accommodate PI(3,4,5)P3. Proteins known to contain a phosphatase and a C2 tensin-type domain are listed below: Tensin, a focal-adhesion molecule that binds to actin filaments. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.Phosphatase and tensin homologue deleted on chromosome 10 protein (PTEN). It antagonizes PI 3-kinase signalling by dephosphorylating the 3-position of the inositol ring of PI(3,4,5)P3 and thus inactivates downstream signalling. It plays major roles both during development and in the adult to control cell size, growth, and survival.Auxilin. It binds clathrin heavy chain and promotes its assembly into regular cages.Cyclin G-associated kinase or auxilin-2. It is a potential regulator of clathrin-mediated membrane trafficking. Short Name:  Tensin_C2-dom

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF10409
PS51182

1 Found In

DB identifier Type Name
IPR017361 Family Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR000008 Domain C2 domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
402115 D8QPM5 PAC:15401967 Selaginella moellendorffii 137  
74599 D8QPN4 PAC:15410807 Selaginella moellendorffii 1100  
165134 D8QSS2 PAC:15411197 Selaginella moellendorffii 610  
77222 D8QS90 PAC:15417080 Selaginella moellendorffii 1121  
91219 D8RCM2 PAC:15414008 Selaginella moellendorffii 393  
evm.model.supercontig_127.30 PAC:16407393 Carica papaya 1033  
evm.model.supercontig_14.140 PAC:16408637 Carica papaya 421  
evm.model.supercontig_200.15 PAC:16413136 Carica papaya 580  
evm.model.supercontig_46.143 PAC:16420426 Carica papaya 940  
evm.model.supercontig_55.99 PAC:16422670 Carica papaya 403  
29696.m000106 PAC:16806080 Ricinus communis 1191  
29801.m003123 B9RYC0 PAC:16808973 Ricinus communis 612  
29827.m002591 B9S1L1 PAC:16810024 Ricinus communis 820  
29848.m004543 B9RNW2 PAC:16811199 Ricinus communis 1266  
30138.m004035 B9RLU7 PAC:16819400 Ricinus communis 1550  
28124.m000233 B9T3S6 PAC:16799974 Ricinus communis 420  
Cucsa.338540.1 A0A0A0LHP2 PAC:16978765 Cucumis sativus 416  
Cucsa.112960.2 PAC:16960250 Cucumis sativus 1236  
Cucsa.112960.1 PAC:16960249 Cucumis sativus 1296  
Cucsa.102650.1 PAC:16958908 Cucumis sativus 307  
Cucsa.149890.1 PAC:16964359 Cucumis sativus 645  
Cucsa.271560.1 PAC:16973548 Cucumis sativus 1385  
Cucsa.197930.3 PAC:16968516 Cucumis sativus 1200  
Cucsa.197930.1 PAC:16968514 Cucumis sativus 1298  
Cucsa.197930.2 PAC:16968515 Cucumis sativus 1236  
Cucsa.197930.4 PAC:16968517 Cucumis sativus 1015  
Cucsa.219620.1 PAC:16969827 Cucumis sativus 405  
Cucsa.351030.1 PAC:16979945 Cucumis sativus 1138  
orange1.1g014325m A0A067GB44 PAC:18135430 Citrus sinensis 426  
orange1.1g001026m A0A067FVH8 PAC:18109294 Citrus sinensis 1184  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10555148
            11395408
            11858936