Protein Domain : IPR017361

Type:  Family Name:  Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
Description:  This entry represents the magnesium-dependent bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN (; ; ), which possesses the following catalytic activities:Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.A phosphoprotein + H(2)O = a protein + phosphate.Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.This protein acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins []. It also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate. The lipid phosphatase activity is critical for its tumour suppressor function []. PTEN antagonizes the PI3K-AKT/PKB signalling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form of PTEN cooperates with AIP1 to suppress AKT1 activation. PTEN dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion form []. Short Name:  Bifunc_PIno_P3_Pase/Pase_PTEN
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0 Child Features

2 Contains

DB identifier Type Name
IPR000340 Domain Dual specificity phosphatase, catalytic domain
IPR014020 Domain Tensin phosphatase, C2 domain

1 Cross References

Identifier
PIRSF038025

0 Found In

13 GO Annotations

GO Term Gene Name
GO:0000287 IPR017361
GO:0004725 IPR017361
GO:0016314 IPR017361
GO:0030165 IPR017361
GO:0051800 IPR017361
GO:0006470 IPR017361
GO:0008285 IPR017361
GO:0030336 IPR017361
GO:0031647 IPR017361
GO:0046855 IPR017361
GO:0046856 IPR017361
GO:0051895 IPR017361
GO:0051898 IPR017361

13 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR017361
GO:0004725 IPR017361
GO:0016314 IPR017361
GO:0030165 IPR017361
GO:0051800 IPR017361
GO:0006470 IPR017361
GO:0008285 IPR017361
GO:0030336 IPR017361
GO:0031647 IPR017361
GO:0046855 IPR017361
GO:0046856 IPR017361
GO:0051895 IPR017361
GO:0051898 IPR017361

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17324556
            18794879
            18838554