| Type: | Family | Name: | Protein kinase C, delta/epsilon/eta/theta types |
| Description: | This entry represents the novel protein kinase C (nPKC) family. The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent [, , ].PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol [, ]. Members of this family play key regulatory roles in various cellular processes. Currently, there are ten isoforms of PKC which can be classified into classical (alpha, beta I, beta II, gamma), novel (delta, epsilon, eta, theta) and atypical (zeta, iota/lambda) types based on their primary structure and biochemical characteristics [, , ]. All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain. | Short Name: | Prot_kin_PKC_delta |
| DB identifier | Type | Name |
|---|---|---|
| IPR002290 | Domain | Serine/threonine/dual specificity protein kinase, catalytic domain |
| IPR000008 | Domain | C2 domain |
| IPR002219 | Domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| IPR017892 | Domain | Protein kinase, C-terminal |
| IPR017441 | Binding_site | Protein kinase, ATP binding site |
| IPR008271 | Active_site | Serine/threonine-protein kinase, active site |
| IPR020454 | Domain | Diacylglycerol/phorbol-ester binding |
