Protein Domain : IPR002290

Type:  Domain Name:  Serine/threonine/dual specificity protein kinase, catalytic domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , ] are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme [].This entry represents the protein kinase catalytic domain found in a number of serine/threonine-protein kinases and dual specificity protein kinases. Short Name:  Ser/Thr_dual-sp_kinase
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0 Child Features

3 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site

1 Cross References

Identifier
SM00220

29 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR008350 Family Mitogen-activated protein (MAP) kinase, ERK3/4
IPR002374 Family cGMP-dependent kinase
IPR016238 Family Ribosomal protein S6 kinase
IPR016237 Family Serine/threonine-protein kinase, Ulk1/Ulk2
IPR016239 Family Ribosomal protein S6 kinase II
IPR016242 Family Serine/threonine-protein kinase Mps1
IPR016256 Family Serine/threonine-protein kinase Rad53
IPR020676 Family Death-associated protein kinase 1
IPR014375 Family Protein kinase C, alpha/beta/gamma types
IPR014376 Family Protein kinase C, delta/epsilon/eta/theta types
IPR020684 Family Rho-associated protein kinase 1/2
IPR015727 Family Protein kinase C mu-related
IPR012233 Family Protein kinase C
IPR017405 Family Citron Rho-interacting kinase
IPR002291 Family Phosphorylase kinase, gamma catalytic subunit
IPR017090 Family Serine/threonine-protein kinase, SIK1/2
IPR017184 Family Serine/threonine-protein kinase Unc-51
IPR017239 Family Mitogen-activated protein (MAP) kinase kinase kinase Ste11, Cryptococcus
IPR000239 Family GPCR kinase
IPR020658 Family Serine/threonine-protein kinase Plk3
IPR020675 Family Myosin light chain kinase-related
IPR020679 Family Serine/threonine-protein kinase Tda1
IPR020682 Family Obscurin-myosin light chain kinase
IPR017240 Family Mitogen-activated protein (MAP) kinase kinase kinase Ssk2/Ssk22
IPR021160 Family Mitogen-activated protein (MAP) kinase kinase kinase kinase
IPR015725 Family Telokin/Myosin light chain kinase
IPR015726 Family Serine/threonine protein kinase, striated muscle-specific

3 GO Annotations

GO Term Gene Name
GO:0004672 IPR002290
GO:0005524 IPR002290
GO:0006468 IPR002290

3 Ontology Annotations

GO Term Gene Name
GO:0004672 IPR002290
GO:0005524 IPR002290
GO:0006468 IPR002290

1 Parent Features

DB identifier Type Name
IPR000719 Domain Protein kinase domain

178533 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
146897 D8RG80 PAC:15405067 Selaginella moellendorffii 409  
146775 D8RFU9 PAC:15404230 Selaginella moellendorffii 266  
17948 D8RFT2 PAC:15401559 Selaginella moellendorffii 145  
17171 D8RFS8 PAC:15417852 Selaginella moellendorffii 185  
3976 D8RFV7 PAC:15416799 Selaginella moellendorffii 154  
4154 D8RFR2 PAC:15413599 Selaginella moellendorffii 180  
92161 D8RFQ3 PAC:15416190 Selaginella moellendorffii 314  
430503 D8T9L9 PAC:15420730 Selaginella moellendorffii 398  
430614 D8T9Y7 PAC:15421407 Selaginella moellendorffii 256  
430604 D8T9X6 PAC:15421393 Selaginella moellendorffii 572  
430601 D8T9X3 PAC:15421388 Selaginella moellendorffii 691  
135200 D8T9X8 PAC:15412584 Selaginella moellendorffii 217  
37511 D8RGZ9 PAC:15412873 Selaginella moellendorffii 166  
411235 D8RH02 PAC:15406964 Selaginella moellendorffii 401  
93150 D8RH00 PAC:15419115 Selaginella moellendorffii 488  
6355 D8TCT1 PAC:15420907 Selaginella moellendorffii 193  
431485 D8TCT6 PAC:15422973 Selaginella moellendorffii 377  
431592 D8TD54 PAC:15401533 Selaginella moellendorffii 731  
35365 D8RLR7 PAC:15405546 Selaginella moellendorffii 239  
172755 D8RMM5 PAC:15414268 Selaginella moellendorffii 357  
56634 PAC:15402743 Selaginella moellendorffii 267  
97070 D8RMM2 PAC:15407596 Selaginella moellendorffii 355  
432162 D8TF62 PAC:15401296 Selaginella moellendorffii 699  
165698 D8QW17 PAC:15415126 Selaginella moellendorffii 866  
165616 D8QVF7 PAC:15414969 Selaginella moellendorffii 604  
27259 D8QUN9 PAC:15403380 Selaginella moellendorffii 180  
28122 D8QVA8 PAC:15405496 Selaginella moellendorffii 166  
230150 D8QVZ4 PAC:15411601 Selaginella moellendorffii 445  
24258 PAC:15417035 Selaginella moellendorffii 282  
404078 D8QU77 PAC:15407086 Selaginella moellendorffii 597  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            7768349
            1835513
            1956325
            1862342