Protein Domain : IPR000719

Type:  Domain Name:  Protein kinase domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , , ] are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine residue, which has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residue which is important for the catalytic activity of the enzyme []. This entry represents the protein kinase domain containing the catalytic function of protein kinases []. This domain is found in serine/threonine-protein kinases, tyrosine-protein kinases and dual specificity protein kinases. Short Name:  Prot_kinase_dom
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3 Child Features

DB identifier Type Name
IPR002290 Domain Serine/threonine/dual specificity protein kinase, catalytic domain
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain
IPR027916 Domain Protein kinase-like domain, Apicomplexa

6 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site

2 Cross Referencess

Identifier
PF00069
PS50011

55 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR008790 Family Poxvirus serine/threonine kinase
IPR008350 Family Mitogen-activated protein (MAP) kinase, ERK3/4
IPR002374 Family cGMP-dependent kinase
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR016248 Family Fibroblast growth factor receptor family
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016237 Family Serine/threonine-protein kinase, Ulk1/Ulk2
IPR016234 Family Serine/threonine-protein kinase, Sbk1
IPR016235 Family Tyrosine/threonine-protein kinase, Cdc2 inhibitor
IPR016241 Family Nitrogen network kinase 1
IPR016240 Family Serine/threonine-protein kinase YKL116C, predicted
IPR016242 Family Serine/threonine-protein kinase Mps1
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR016250 Family Tyrosine-protein kinase, Fes/Fps type
IPR016256 Family Serine/threonine-protein kinase Rad53
IPR016257 Family Ephrin receptor type-A /type-B
IPR020691 Family Ephrin type-A receptor 8
IPR020676 Family Death-associated protein kinase 1
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor

3 GO Annotations

GO Term Gene Name
GO:0004672 IPR000719
GO:0005524 IPR000719
GO:0006468 IPR000719

3 Ontology Annotations

GO Term Gene Name
GO:0004672 IPR000719
GO:0005524 IPR000719
GO:0006468 IPR000719

1 Parent Features

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain

542305 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
5023 D8T8S9 PAC:15415688 Selaginella moellendorffii 54  
134757 D8T936 PAC:15413620 Selaginella moellendorffii 122  
146738 D8RFQ8 PAC:15404136 Selaginella moellendorffii 988  
146686 D8RFG7 PAC:15403485 Selaginella moellendorffii 324  
146897 D8RG80 PAC:15405067 Selaginella moellendorffii 409  
146775 D8RFU9 PAC:15404230 Selaginella moellendorffii 266  
171183 D8RG24 PAC:15406707 Selaginella moellendorffii 360  
171048 D8RFP6 PAC:15405831 Selaginella moellendorffii 990  
17948 D8RFT2 PAC:15401559 Selaginella moellendorffii 145  
17171 D8RFS8 PAC:15417852 Selaginella moellendorffii 185  
171221 PAC:15407246 Selaginella moellendorffii 335  
3976 D8RFV7 PAC:15416799 Selaginella moellendorffii 154  
410522 D8RF08 PAC:15406363 Selaginella moellendorffii 631  
410738 D8RFQ4 PAC:15407860 Selaginella moellendorffii 295  
4154 D8RFR2 PAC:15413599 Selaginella moellendorffii 180  
440878 D8RF40 PAC:15407973 Selaginella moellendorffii 441  
92161 D8RFQ3 PAC:15416190 Selaginella moellendorffii 314  
66995 D8RFH0 PAC:15412495 Selaginella moellendorffii 282  
92324 D8RG30 PAC:15417625 Selaginella moellendorffii 204  
92819 PAC:15421298 Selaginella moellendorffii 1253  
92726 D8RF67 PAC:15420653 Selaginella moellendorffii 504  
93043 D8RF66 PAC:15418284 Selaginella moellendorffii 544  
92988 D8RFM9 PAC:15422220 Selaginella moellendorffii 354  
430503 D8T9L9 PAC:15420730 Selaginella moellendorffii 398  
430614 D8T9Y7 PAC:15421407 Selaginella moellendorffii 256  
430604 D8T9X6 PAC:15421393 Selaginella moellendorffii 572  
430601 D8T9X3 PAC:15421388 Selaginella moellendorffii 691  
135200 D8T9X8 PAC:15412584 Selaginella moellendorffii 217  
146942 D8RHJ9 PAC:15405750 Selaginella moellendorffii 332  
13423 D8RGJ9 PAC:15408272 Selaginella moellendorffii 351  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            7768349
            1835513
            1956325
            1862342
            12734000