| Type: | Family | Name: | Ephrin type-A receptor 8 |
| Description: | Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents ephrin type-A receptor 8, which is a receptor tyrosine kinase that binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighbouring cells []. | Short Name: | EphrinA_rcpt8 |
| DB identifier | Type | Name |
|---|---|---|
| IPR000719 | Domain | Protein kinase domain |
| IPR020635 | Domain | Tyrosine-protein kinase, catalytic domain |
| IPR011009 | Domain | Protein kinase-like domain |
| IPR001245 | Domain | Serine-threonine/tyrosine-protein kinase catalytic domain |
| IPR009030 | Domain | Insulin-like growth factor binding protein, N-terminal |
| IPR000494 | Domain | Receptor L-domain |
| IPR006212 | Repeat | Furin-like repeat |
| IPR017441 | Binding_site | Protein kinase, ATP binding site |
| IPR006211 | Domain | Furin-like cysteine-rich domain |
