Protein Domain : IPR020635

Type:  Domain Name:  Tyrosine-protein kinase, catalytic domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases []. Short Name:  Tyr_kinase_cat_dom
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0 Child Features

4 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site

1 Cross References

Identifier
SM00219

23 Found Ins

DB identifier Type Name
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR016248 Family Fibroblast growth factor receptor family
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016249 Family Tyrosine-protein kinase, Ret receptor
IPR016245 Family Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR016244 Family Tyrosine-protein kinase, HGF/MSP receptor
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR016250 Family Tyrosine-protein kinase, Fes/Fps type
IPR016257 Family Ephrin receptor type-A /type-B
IPR020691 Family Ephrin type-A receptor 8
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR012234 Family Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)

2 GO Annotations

GO Term Gene Name
GO:0004713 IPR020635
GO:0006468 IPR020635

2 Ontology Annotations

GO Term Gene Name
GO:0004713 IPR020635
GO:0006468 IPR020635

1 Parent Features

DB identifier Type Name
IPR001245 Domain Serine-threonine/tyrosine-protein kinase catalytic domain

320187 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
146686 D8RFG7 PAC:15403485 Selaginella moellendorffii 324  
171183 D8RG24 PAC:15406707 Selaginella moellendorffii 360  
171221 PAC:15407246 Selaginella moellendorffii 335  
410738 D8RFQ4 PAC:15407860 Selaginella moellendorffii 295  
66995 D8RFH0 PAC:15412495 Selaginella moellendorffii 282  
92324 D8RG30 PAC:15417625 Selaginella moellendorffii 204  
92726 D8RF67 PAC:15420653 Selaginella moellendorffii 504  
93043 D8RF66 PAC:15418284 Selaginella moellendorffii 544  
92988 D8RFM9 PAC:15422220 Selaginella moellendorffii 354  
146942 D8RHJ9 PAC:15405750 Selaginella moellendorffii 332  
13423 D8RGJ9 PAC:15408272 Selaginella moellendorffii 351  
6275 D8TAI1 PAC:15420202 Selaginella moellendorffii 174  
65208 D8RHS9 PAC:15403846 Selaginella moellendorffii 304  
93421 D8RGH9 PAC:15421188 Selaginella moellendorffii 360  
93690 D8RHN8 PAC:15422860 Selaginella moellendorffii 302  
135824 C4P7R6 PAC:15417184 Selaginella moellendorffii 432  
135805 D8TAW1 PAC:15417148 Selaginella moellendorffii 661  
231705 D8RIH2 PAC:15419009 Selaginella moellendorffii 364  
236704 D8TCF5 PAC:15411296 Selaginella moellendorffii 339  
44342 D8TCU8 PAC:15409829 Selaginella moellendorffii 325  
37866 D8RKA8 PAC:15415352 Selaginella moellendorffii 178  
24657 PAC:15420081 Selaginella moellendorffii 330  
172224 D8RKK4 PAC:15410332 Selaginella moellendorffii 930  
96034 D8RKR2 PAC:15404581 Selaginella moellendorffii 496  
95819 D8RK06 PAC:15407752 Selaginella moellendorffii 337  
412742 D8RLB8 PAC:15413951 Selaginella moellendorffii 2102  
55695 D8RLQ2 PAC:15422250 Selaginella moellendorffii 262  
96761 D8RLI3 PAC:15410155 Selaginella moellendorffii 314  
172624 D8RMA6 PAC:15413430 Selaginella moellendorffii 662  
30736 D8RMI8 PAC:15416314 Selaginella moellendorffii 596  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712
            19275641
            16700535
            15845350