Protein Domain : IPR001245

Type:  Domain Name:  Serine-threonine/tyrosine-protein kinase catalytic domain
Description:  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include catalytic domain of dual specificity kinases. Short Name:  Ser-Thr/Tyr_kinase_cat_dom
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1 Child Features

DB identifier Type Name
IPR020635 Domain Tyrosine-protein kinase, catalytic domain

4 Contains

DB identifier Type Name
IPR017441 Binding_site Protein kinase, ATP binding site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site

2 Cross Referencess

Identifier
PF07714
PR00109

25 Found Ins

DB identifier Type Name
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR016248 Family Fibroblast growth factor receptor family
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016249 Family Tyrosine-protein kinase, Ret receptor
IPR016245 Family Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR016244 Family Tyrosine-protein kinase, HGF/MSP receptor
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR016250 Family Tyrosine-protein kinase, Fes/Fps type
IPR016257 Family Ephrin receptor type-A /type-B
IPR020691 Family Ephrin type-A receptor 8
IPR020461 Family Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020446 Family Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020455 Family Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020777 Family Tyrosine-protein kinase, neurotrophic receptor
IPR012234 Family Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR017419 Family Mitogen-activated protein kinase kinase kinase 12/13
IPR020766 Family Receptor-like tyrosine-protein kinase kin-15/kin-16
IPR009136 Family Vascular endothelial growth factor receptor 2 (VEGFR2)
IPR017421 Family Mitogen-activated protein (MAP) kinase kinase kinase 7

2 GO Annotations

GO Term Gene Name
GO:0004672 IPR001245
GO:0006468 IPR001245

2 Ontology Annotations

GO Term Gene Name
GO:0004672 IPR001245
GO:0006468 IPR001245

1 Parent Features

DB identifier Type Name
IPR000719 Domain Protein kinase domain

270734 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134757 D8T936 PAC:15413620 Selaginella moellendorffii 122  
146897 D8RG80 PAC:15405067 Selaginella moellendorffii 409  
146775 D8RFU9 PAC:15404230 Selaginella moellendorffii 266  
171048 D8RFP6 PAC:15405831 Selaginella moellendorffii 990  
171221 PAC:15407246 Selaginella moellendorffii 335  
3976 D8RFV7 PAC:15416799 Selaginella moellendorffii 154  
410738 D8RFQ4 PAC:15407860 Selaginella moellendorffii 295  
4154 D8RFR2 PAC:15413599 Selaginella moellendorffii 180  
92819 PAC:15421298 Selaginella moellendorffii 1253  
93043 D8RF66 PAC:15418284 Selaginella moellendorffii 544  
92988 D8RFM9 PAC:15422220 Selaginella moellendorffii 354  
430614 D8T9Y7 PAC:15421407 Selaginella moellendorffii 256  
430604 D8T9X6 PAC:15421393 Selaginella moellendorffii 572  
430601 D8T9X3 PAC:15421388 Selaginella moellendorffii 691  
135200 D8T9X8 PAC:15412584 Selaginella moellendorffii 217  
146942 D8RHJ9 PAC:15405750 Selaginella moellendorffii 332  
13423 D8RGJ9 PAC:15408272 Selaginella moellendorffii 351  
37511 D8RGZ9 PAC:15412873 Selaginella moellendorffii 166  
93421 D8RGH9 PAC:15421188 Selaginella moellendorffii 360  
231705 D8RIH2 PAC:15419009 Selaginella moellendorffii 364  
236704 D8TCF5 PAC:15411296 Selaginella moellendorffii 339  
21370 D8TCC5 PAC:15409018 Selaginella moellendorffii 448  
44342 D8TCU8 PAC:15409829 Selaginella moellendorffii 325  
431485 D8TCT6 PAC:15422973 Selaginella moellendorffii 377  
172284 D8RKT5 PAC:15410477 Selaginella moellendorffii 1015  
24657 PAC:15420081 Selaginella moellendorffii 330  
172224 D8RKK4 PAC:15410332 Selaginella moellendorffii 930  
95819 D8RK06 PAC:15407752 Selaginella moellendorffii 337  
31503 D8TDW5 PAC:15417648 Selaginella moellendorffii 525  
35365 D8RLR7 PAC:15405546 Selaginella moellendorffii 239  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3291115
            12368087
            12471243
            15078142
            15320712