Protein Domain : IPR009030

Type:  Domain Name:  Insulin-like growth factor binding protein, N-terminal
Description:  The growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [], the type-1 insulin-like growth-factor receptor (IGF-1R) [], and the receptor protein-tyrosine kinase Erbb-3 (ErbB3) []. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides. IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organisation, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues. IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain. ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure. Short Name:  Growth_fac_rcpt_N_dom
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2 Child Features

DB identifier Type Name
IPR000867 Domain Insulin-like growth factor-binding protein, IGFBP
IPR006211 Domain Furin-like cysteine-rich domain

4 Contains

DB identifier Type Name
IPR011936 Repeat Myxococcus cysteine-rich repeat
IPR011641 Domain Tyrosine-protein kinase ephrin type A/B receptor-like
IPR006212 Repeat Furin-like repeat
IPR003341 Repeat Cysteine rich repeat, tripleX

2 Cross Referencess

Identifier
G3DSA:4.10.40.20
SSF57184

13 Found Ins

DB identifier Type Name
IPR005127 Family Giardia variant-specific surface protein
IPR016324 Family Thyroglobulin
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR020691 Family Ephrin type-A receptor 8
IPR011398 Family Fibrillin
IPR012210 Family Insulin-like growth factor binding protein 2
IPR022321 Family Insulin-like growth factor-binding protein family 1-6, chordata
IPR012213 Family Insulin-like growth factor binding protein 5
IPR012211 Family Insulin-like growth factor binding protein 3
IPR022322 Family Insulin-like growth factor-binding protein 1
IPR022326 Family Insulin-like growth factor-binding protein 6
IPR022327 Family Insulin-like growth factor-binding protein 4
IPR009168 Family Insulin-like growth factor binding protein

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413345 D8RP60 PAC:15413779 Selaginella moellendorffii 516  
98651 D8RPL3 PAC:15415239 Selaginella moellendorffii 1427  
415652 D8RWT7 PAC:15421758 Selaginella moellendorffii 291  
420096 D8SAY9 PAC:15409945 Selaginella moellendorffii 110  
423653 D8SME2 PAC:15423106 Selaginella moellendorffii 528  
evm.model.supercontig_171.26 PAC:16410911 Carica papaya 790  
evm.model.supercontig_54.82 PAC:16422438 Carica papaya 555  
evm.model.supercontig_717.1 PAC:16425501 Carica papaya 228  
29755.m000427 B9SNI7 PAC:16807930 Ricinus communis 739  
29755.m000429 B9SNI9 PAC:16807932 Ricinus communis 771  
29912.m005348 B9RKE2 PAC:16813225 Ricinus communis 1195  
29976.m000491 B9SD70 PAC:16814779 Ricinus communis 457  
29994.m000441 B9SQ66 PAC:16815358 Ricinus communis 181  
29628.m000784 B9SS28 PAC:16803927 Ricinus communis 1181  
29628.m000749 B9SRZ3 PAC:16803892 Ricinus communis 373  
29648.m001949 B9S2R0 PAC:16804791 Ricinus communis 1433  
Cucsa.111190.1 PAC:16960004 Cucumis sativus 668  
Cucsa.116830.1 PAC:16960631 Cucumis sativus 1436  
Cucsa.160990.1 A0A0A0LLG8 PAC:16965442 Cucumis sativus 1448  
orange1.1g044046m A0A067DQ19 PAC:18093800 Citrus sinensis 175  
orange1.1g035932m A0A067D112 PAC:18094268 Citrus sinensis 433  
orange1.1g006402m A0A067F1H2 PAC:18124122 Citrus sinensis 646  
orange1.1g002008m PAC:18123590 Citrus sinensis 983  
orange1.1g000508m PAC:18096324 Citrus sinensis 1457  
orange1.1g001283m PAC:18096330 Citrus sinensis 1108  
orange1.1g000613m PAC:18096325 Citrus sinensis 1391  
orange1.1g000507m PAC:18096323 Citrus sinensis 1458  
orange1.1g000752m PAC:18096326 Citrus sinensis 1303  
orange1.1g000976m PAC:18096327 Citrus sinensis 1204  
orange1.1g001282m PAC:18096329 Citrus sinensis 1108  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9690478
            11447105
            12154198