1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR022321 | Family | Insulin-like growth factor-binding protein family 1-6, chordata |
| Type: | Family | Name: | Insulin-like growth factor-binding protein 6 |
| Description: | Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types []. In biological fluids, these growth factors are usually bound to IGF binding proteins (IGFBPs), which regulate their availability and activity by prolonging their half-life and modulating their receptor interactions. To date, six IGFBP family members have been identified (termed IGFBP1-6) []. They share a conserved gene (intron-exon) organisation and high IGF binding affinity. Structurally, the proteins also share a common domain architecture, possessing a conserved N-terminal IGFBP domain, a highly variable mid-section, and a thyroglobulin type-1 (Tg1) domain in their C-terminal regions. In addition to their role in the regulation of IGF activity, there is evidence for the direct association of IGFBPs with a variety of extracellular and cell surface molecules [, ], with consequent effects upon important biological processes. These include modulation of bone cell proliferation [], and growth arrest of breast and prostate cancer cells [, ]. IGFBP6 is a potent inducer of programmed cell death in lung cancer cells []. The protein may therefore represent a potential target as a cancer therapeutic. | Short Name: | IGFBP-6 |
| DB identifier | Type | Name |
|---|---|---|
| IPR022321 | Family | Insulin-like growth factor-binding protein family 1-6, chordata |
