Protein Domain : IPR022321

Type:  Family Name:  Insulin-like growth factor-binding protein family 1-6, chordata
Description:  Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types []. In biological fluids, these growth factors are usually bound to IGF-binding proteins (IGFBPs), which regulate their availability and activity by prolonging their half-life and modulating their receptor interactions. To date, six IGFBP family members have been identified (termed IGFBP1-6) []. They share a conserved gene (intron-exon) organisation and high IGF-binding affinity. Structurally, the proteins also share a common domain architecture, possessing a conserved N-terminal IGFBP domain, a highly variable mid-section, and a thyroglobulin type-1 (Tg1) domain in their C-terminal regions. In addition to their role in the regulation of IGF activity, there is evidence for the direct association of IGFBPs with a variety of extracellular and cell surface molecules [, ], with consequent effects upon important biological processes. These include modulation of bone cell proliferation [], and growth arrest of breast and prostate cancer cells [, ]. Short Name:  IGFBP_1-6_chordata
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6 Child Features

DB identifier Type Name
IPR012210 Family Insulin-like growth factor binding protein 2
IPR012213 Family Insulin-like growth factor binding protein 5
IPR012211 Family Insulin-like growth factor binding protein 3
IPR022322 Family Insulin-like growth factor-binding protein 1
IPR022326 Family Insulin-like growth factor-binding protein 6
IPR022327 Family Insulin-like growth factor-binding protein 4

2 Contains

DB identifier Type Name
IPR009030 Domain Insulin-like growth factor binding protein, N-terminal
IPR000716 Domain Thyroglobulin type-1

1 Cross References

Identifier
PR01976

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0005520 IPR022321
GO:0005576 IPR022321

2 Ontology Annotations

GO Term Gene Name
GO:0005520 IPR022321
GO:0005576 IPR022321

1 Parent Features

DB identifier Type Name
IPR009168 Family Insulin-like growth factor binding protein

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8874492
            10605625
            7504671
            7499327
            7544787
            9115291