Protein Domain : IPR011009

Type:  Domain Name:  Protein kinase-like domain
Description:  Protein kinases () modify other proteins by chemically adding phosphate groups to them. This process is fundamental to most signalling and regulatory processes in the eukaryotic cell []. The protein kinases contain a catalytic core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond. The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include: the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and, as such, is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion [] choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine [] 3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics [] This entry represents the protein-kinase domain and other related domains that share a similar structure. Short Name:  Kinase-like_dom
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8 Child Features

DB identifier Type Name
IPR000719 Domain Protein kinase domain
IPR004147 Domain UbiB domain
IPR002575 Domain Aminoglycoside phosphotransferase
IPR000687 Domain RIO kinase
IPR000403 Domain Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR015275 Domain Actin-fragmin kinase, catalytic domain
IPR004166 Domain MHCK/EF2 kinase
IPR015897 Domain CHK kinase-like

10 Contains

DB identifier Type Name
IPR007521 Domain Choline kinase, N-terminal
IPR003605 Domain GS domain
IPR018936 Conserved_site Phosphatidylinositol 3/4-kinase, conserved site
IPR018935 Conserved_site RIO kinase, conserved site
IPR017441 Binding_site Protein kinase, ATP binding site
IPR008271 Active_site Serine/threonine-protein kinase, active site
IPR001824 Conserved_site Tyrosine-protein kinase, receptor class III, conserved site
IPR008266 Active_site Tyrosine-protein kinase, active site
IPR002011 Conserved_site Tyrosine-protein kinase, receptor class II, conserved site
IPR003527 Conserved_site Mitogen-activated protein (MAP) kinase, conserved site

1 Cross References

Identifier
SSF56112

60 Found Ins

DB identifier Type Name
IPR020636 Family Calcium/calmodulin-dependent/calcium-dependent protein kinase
IPR017407 Family Serine/threonine-protein kinase Rio1
IPR015433 Family Phosphatidylinositol Kinase
IPR017348 Family Serine/threonine-protein kinase pim-1/2/3
IPR016243 Family Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR010232 Family Probable protein kinase UbiB
IPR008350 Family Mitogen-activated protein (MAP) kinase, ERK3/4
IPR002374 Family cGMP-dependent kinase
IPR017400 Family Eukaryotic elongation factor 2 kinase
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR008290 Family Phosphatidylinositol 3-kinase, Vps34 type
IPR017406 Family Serine/threonine-protein kinase Rio3
IPR016248 Family Fibroblast growth factor receptor family
IPR016231 Family Mitogen-activated protein (MAP) kinase kinase kinase, MLK1/MLK2/MLK4
IPR015785 Family Mitogen-activated protein (MAP) kinase kinase kinase 10
IPR016237 Family Serine/threonine-protein kinase, Ulk1/Ulk2
IPR016234 Family Serine/threonine-protein kinase, Sbk1
IPR016235 Family Tyrosine/threonine-protein kinase, Cdc2 inhibitor
IPR016241 Family Nitrogen network kinase 1
IPR016240 Family Serine/threonine-protein kinase YKL116C, predicted
IPR016242 Family Serine/threonine-protein kinase Mps1
IPR016247 Family Tyrosine-protein kinase, receptor ROR
IPR016246 Family Tyrosine-protein kinase, insulin-like receptor
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1
IPR016250 Family Tyrosine-protein kinase, Fes/Fps type
IPR016256 Family Serine/threonine-protein kinase Rad53
IPR016257 Family Ephrin receptor type-A /type-B
IPR020691 Family Ephrin type-A receptor 8

0 GO Annotation

0 Ontology Annotations

0 Parent Features

525542 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
5023 D8T8S9 PAC:15415688 Selaginella moellendorffii 54  
134757 D8T936 PAC:15413620 Selaginella moellendorffii 122  
146738 D8RFQ8 PAC:15404136 Selaginella moellendorffii 988  
146686 D8RFG7 PAC:15403485 Selaginella moellendorffii 324  
146897 D8RG80 PAC:15405067 Selaginella moellendorffii 409  
146775 D8RFU9 PAC:15404230 Selaginella moellendorffii 266  
171183 D8RG24 PAC:15406707 Selaginella moellendorffii 360  
171048 D8RFP6 PAC:15405831 Selaginella moellendorffii 990  
17948 D8RFT2 PAC:15401559 Selaginella moellendorffii 145  
17171 D8RFS8 PAC:15417852 Selaginella moellendorffii 185  
171221 PAC:15407246 Selaginella moellendorffii 335  
3976 D8RFV7 PAC:15416799 Selaginella moellendorffii 154  
410522 D8RF08 PAC:15406363 Selaginella moellendorffii 631  
410623 D8RFB9 PAC:15407056 Selaginella moellendorffii 436  
410738 D8RFQ4 PAC:15407860 Selaginella moellendorffii 295  
4154 D8RFR2 PAC:15413599 Selaginella moellendorffii 180  
440878 D8RF40 PAC:15407973 Selaginella moellendorffii 441  
92161 D8RFQ3 PAC:15416190 Selaginella moellendorffii 314  
66995 D8RFH0 PAC:15412495 Selaginella moellendorffii 282  
92324 D8RG30 PAC:15417625 Selaginella moellendorffii 204  
92881 D8RG08 PAC:15421425 Selaginella moellendorffii 725  
92819 PAC:15421298 Selaginella moellendorffii 1253  
92726 D8RF67 PAC:15420653 Selaginella moellendorffii 504  
430403 D8T9B1 PAC:15419975 Selaginella moellendorffii 492  
93043 D8RF66 PAC:15418284 Selaginella moellendorffii 544  
92988 D8RFM9 PAC:15422220 Selaginella moellendorffii 354  
430503 D8T9L9 PAC:15420730 Selaginella moellendorffii 398  
430614 D8T9Y7 PAC:15421407 Selaginella moellendorffii 256  
430604 D8T9X6 PAC:15421393 Selaginella moellendorffii 572  
430601 D8T9X3 PAC:15421388 Selaginella moellendorffii 691  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12191603
            11090628
            12791258
            11467935