Protein Domain : IPR003605

Type:  Domain Name:  GS domain
Description:  Transforming growth factor beta (TGF-beta) is a member of a large family of secreted growth factors of central importance in eukaryotic development andhomeostasis. Members of this family, which includes the activins, inhibins and bone morphogenic proteins (BMPs), bind to receptors that consist of twotransmembrane serine/threonine (Ser/Thr) kinases called the type I and type II receptors. Type II activates Type Iupon formation of the ligand receptor complex by multiply phosphorylating the GS domain, a short (~30 residues), highly conserved regulatory sequence justN-terminal to the kinase domain on the cytoplasmic side of the receptor. The GS domain is found only in the type I receptor family and is named for theTTSGSGSG sequence at its core. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fullyactivate TbetaR-1 [].The GS domain forms a helix-loop-helix structure in which the sites of activating phosphorylation are situated in a loop known as the GS loop. One key role for phosphorylation is to block the adoption of aninactivating configuration by the GS domain []. Short Name:  GS_dom
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF08515
PS51256
SM00467

1 Found In

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain

4 GO Annotations

GO Term Gene Name
GO:0004675 IPR003605
GO:0005524 IPR003605
GO:0006468 IPR003605
GO:0016020 IPR003605

4 Ontology Annotations

GO Term Gene Name
GO:0004675 IPR003605
GO:0005524 IPR003605
GO:0006468 IPR003605
GO:0016020 IPR003605

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
arahy.Tifrunner.gnm1.ann1.1Z4Y0D.1 PAC:42620578 Arachis hypogaea 163  
arahy.Tifrunner.gnm1.ann1.EC2A8B.1 PAC:42633575 Arachis hypogaea 163  
augustus_masked-Fvb4-3-processed-gene-103.11-mRNA-1 PAC:50474132 Fragaria x ananassa 100  
augustus_masked-Fvb4-3-processed-gene-103.10-mRNA-1 PAC:50476356 Fragaria x ananassa 100  
snap_masked-Fvb4-2-processed-gene-71.37-mRNA-1 PAC:50531529 Fragaria x ananassa 153  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11583628
            10025408