Protein Domain : IPR015433

Type:  Family Name:  Phosphatidylinositol Kinase
Description:  This group of proteins is comprised entirely of phosphatidylinositol 3- and phosphatidylinositol 4-kinases. Phosphatidylinositol 3-kinase (PI3-kinase) [] is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The three products of PI3-kinase, PI-3-P, PI-3,4-P(2) and PI-3,4,5-P(3), function as secondary messengers in cell signalling. Phosphatidylinositol 4-kinase (PI4-kinase) [] acts on phosphatidylinositol (PI) in the first committed step of the production of the secondary messenger inositol-1,4,5-trisphosphate. The PI3- and PI4-kinases share a well-conserved domain at their C-terminal section, which is distantly related to the catalytic domain of protein kinases [, ]. The catalytic domain of PI3K has a bilobal structure with a small N-terminal lobe and a large C-terminal lobe; this structure is often found in other ATP-dependent kinases. The core of this catalytic domain is the most conserved region of the PI3Ks. The ATP cofactor binds in the crevice formed by the N-and C-terminal lobes, a loop between two strands provides a hydrophobic pocket for binding of the adenine moiety, and a lysine residue interacts with the alpha-phosphate. In contrast to other protein kinases, the PI3K loop interacts with the phosphates of the ATP, known as the glycine-rich or P-loop, contains no glycine residues. Instead, contact with the ATP -phosphate is maintained through the side chain of a conserved serine residue. Short Name:  PI_Kinase
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2 Child Features

DB identifier Type Name
IPR027003 Family Phosphatidylinositol 4-kinase
IPR008290 Family Phosphatidylinositol 3-kinase, Vps34 type

7 Contains

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain
IPR000403 Domain Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Domain Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Domain Phosphatidylinositol 3-kinase, C2 domain
IPR000341 Domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR018936 Conserved_site Phosphatidylinositol 3/4-kinase, conserved site
IPR003113 Domain Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain

1 Cross References

Identifier
PTHR10048

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0046854 IPR015433
GO:0048015 IPR015433

2 Ontology Annotations

GO Term Gene Name
GO:0046854 IPR015433
GO:0048015 IPR015433

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92319 D8RG87 PAC:15417597 Selaginella moellendorffii 1744  
269945 D8TAD9 PAC:15420906 Selaginella moellendorffii 957  
97360 D8RMQ9 PAC:15410005 Selaginella moellendorffii 803  
97324 D8RMV0 PAC:15409901 Selaginella moellendorffii 1072  
109582 D8S5T6 PAC:15405049 Selaginella moellendorffii 457  
118849 D8SKG0 PAC:15411645 Selaginella moellendorffii 790  
evm.model.supercontig_42.143 PAC:16419727 Carica papaya 1102  
evm.model.supercontig_62.125 PAC:16423923 Carica papaya 1151  
evm.model.supercontig_62.126 PAC:16423924 Carica papaya 684  
evm.model.supercontig_69.63 PAC:16424935 Carica papaya 814  
29851.m002434 B9RZB3 PAC:16811461 Ricinus communis 2017  
30136.m001047 B9RU39 PAC:16819175 Ricinus communis 1029  
29631.m001016 B9SH94 PAC:16804098 Ricinus communis 813  
Cucsa.394240.1 A0A0A0LQK5 PAC:16983158 Cucumis sativus 814  
Cucsa.394240.2 PAC:16983159 Cucumis sativus 781  
Cucsa.109760.1 PAC:16959932 Cucumis sativus 315  
Cucsa.109740.1 PAC:16959930 Cucumis sativus 742  
Cucsa.109750.1 PAC:16959931 Cucumis sativus 772  
Cucsa.100930.2 A0A0A0KIZ9 PAC:16958613 Cucumis sativus 1094  
Cucsa.100930.1 A0A0A0KIZ9 PAC:16958612 Cucumis sativus 1094  
Cucsa.240410.1 PAC:16970887 Cucumis sativus 2028  
orange1.1g045995m A0A067EWS1 PAC:18123352 Citrus sinensis 1129  
orange1.1g000157m A0A067DTR9 PAC:18094741 Citrus sinensis 2015  
orange1.1g003462m A0A067GRY2 PAC:18102188 Citrus sinensis 818  
orange1.1g004173m A0A067GUM1 PAC:18102190 Citrus sinensis 770  
orange1.1g004650m A0A067GRP7 PAC:18102191 Citrus sinensis 740  
orange1.1g003651m A0A067H4A2 PAC:18102189 Citrus sinensis 805  
orange1.1g005800m A0A067H3V3 PAC:18102192 Citrus sinensis 676  
AT5G09350.1 Q0WPX9 PAC:19667361 Arabidopsis thaliana 1116  
AT5G64070.1 Q9FMJ0 PAC:19672968 Arabidopsis thaliana 1121  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1322797
            8387896
            8194527
            12151228