Protein Domain : IPR017400

Type:  Family Name:  Eukaryotic elongation factor 2 kinase
Description:  This entry represents elongation factor 2 kinase (eEF-2 kinase), a highly specific kinase that phosphorylates and inactivates eukaryotic elongation factor-2 (eEF-2), and thus can modulate the rate of polypeptide chain elongation during translation. eEF-2 kinase is part of the family of alpha-kinases, whose catalytic domains display no sequence homology to conventional eukaryotic protein kinases []. This family also includes Dictyostelium myosin heavy chain kinases A, B, and C, and several mammalian putative protein kinases. The domain organisation of eEF-2 kinase appears to consist of two domains connected by a linker region, where the N-terminal domain contains the catalytic site, and the C-terminal domain contains the eEF-2 target region. The calmodulin-binding region is located between residues 51 and 96 []. Short Name:  eEF-2K
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0 Child Features

4 Contains

DB identifier Type Name
IPR011009 Domain Protein kinase-like domain
IPR011990 Domain Tetratricopeptide-like helical domain
IPR006597 Repeat Sel1-like repeat
IPR004166 Domain MHCK/EF2 kinase

1 Cross References

Identifier
PIRSF038139

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004686 IPR017400
GO:0005509 IPR017400
GO:0005516 IPR017400
GO:0006468 IPR017400

4 Ontology Annotations

GO Term Gene Name
GO:0004686 IPR017400
GO:0005509 IPR017400
GO:0005516 IPR017400
GO:0006468 IPR017400

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11904175
            11015200