Protein Domain : IPR011990

Type:  Domain Name:  Tetratricopeptide-like helical domain
Description:  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed that TPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within a single TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface is contributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B. This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains, including the tetratricopeptide repeat (TPR) (found in kinesin light chains, SNAP regulatory proteins, clathrin heavy chains and bacterial aspartyl-phosphate phosphatases), and the pentatricopeptide repeat (PPR) (RNA-processing proteins). The TPR is likely to be an ancient repeat, since it is found in eukaryotes, bacteria and archaea, whereas the PPR repeat is found predominantly in higher plants. The superhelix formed from these repeats can bind ligands at a number of different regions, and has the ability to acquire multiple functional roles []. Short Name:  TPR-like_helical_dom
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0 Child Features

10 Contains

DB identifier Type Name
IPR013026 Domain Tetratricopeptide repeat-containing domain
IPR013105 Repeat Tetratricopeptide repeat 2
IPR003107 Repeat HAT (Half-A-TPR) repeat
IPR006597 Repeat Sel1-like repeat
IPR001440 Repeat Tetratricopeptide repeat 1
IPR011717 Repeat Tetratricopeptide TPR-4
IPR019544 Domain Tetratricopeptide, SHNi-TPR domain
IPR011716 Repeat Tetratricopeptide TPR-3
IPR015792 Repeat Kinesin light chain repeat
IPR019568 Domain Rapsyn, myristoylation/linker region, N-terminal

1 Cross References

Identifier
G3DSA:1.25.40.10

28 Found Ins

DB identifier Type Name
IPR013940 Family Meiosis specific protein Spo22/ZIP4/TEX11
IPR010547 Family Plant specific mitochondrial import receptor subunit TOM20
IPR021183 Family N-terminal acetyltransferase A, auxiliary subunit
IPR016543 Family Mitochondria fission 1 protein
IPR000744 Family NSF attachment protein
IPR016341 Family Clathrin, heavy chain
IPR006822 Family Coatomer, epsilon subunit
IPR017689 Family Outer membrane protein assembly factor BamD
IPR005158 Domain Bacterial transcriptional activator domain
IPR002151 Family Kinesin light chain
IPR013360 Family Pilus biogenesis/stability type IV, PilW
IPR017400 Family Eukaryotic elongation factor 2 kinase
IPR016379 Family Type III secretion system, low calcium response, chaperone LcrH/SycD, subgroup
IPR005415 Family Type III secretion system, low calcium response, chaperone LcrH/SycD
IPR014162 Domain Tol-Pal system, YbgF
IPR016684 Family Type III secretion system chaperone, YscY
IPR016931 Family Uncharacterised conserved protein UCP029658, TPR
IPR016982 Family Uncharacterised conserved protein UCP031802
IPR014266 Family PEP-CTERM system TPR-repeat lipoprotein, putative
IPR014562 Family Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing
IPR014596 Family Uncharacterised conserved protein UCP035836
IPR014460 Family Signal transduction response regulator, predicted, VieB
IPR009211 Family Predicted virulence protein, SciE type
IPR001237 Family 43kDa postsynaptic protein
IPR005254 Family Heme biosynthesis-associated TPR protein
IPR005687 Family Mitochondrial outer membrane translocase complex, subunit Tom70
IPR011236 Family Serine/threonine protein phosphatase 5
IPR003921 Family Cellulose synthase, subunit C

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR011990

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR011990

0 Parent Features

238883 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134715 D8T911 PAC:15413529 Selaginella moellendorffii 460  
134581 D8T8Y5 PAC:15412112 Selaginella moellendorffii 771  
430370 D8T973 PAC:15419368 Selaginella moellendorffii 428  
134788 D8T990 PAC:15413706 Selaginella moellendorffii 464  
16806 D8RF93 PAC:15420141 Selaginella moellendorffii 171  
171141 D8RFY4 PAC:15406590 Selaginella moellendorffii 398  
171135 D8RFY1 PAC:15406565 Selaginella moellendorffii 829  
231366 D8RF07 PAC:15416091 Selaginella moellendorffii 484  
410602 D8RF94 PAC:15407011 Selaginella moellendorffii 538  
440903 D8RF87 PAC:15408619 Selaginella moellendorffii 421  
62156 D8RFF1 PAC:15416895 Selaginella moellendorffii 321  
92207 D8RFB3 PAC:15416794 Selaginella moellendorffii 457  
92231 D8RF90 PAC:15416878 Selaginella moellendorffii 789  
92172 D8RFN1 PAC:15416204 Selaginella moellendorffii 554  
92471 D8RF86 PAC:15418474 Selaginella moellendorffii 689  
92426 D8RFJ2 PAC:15418386 Selaginella moellendorffii 265  
92492 D8RFC6 PAC:15418518 Selaginella moellendorffii 331  
92328 D8RG95 PAC:15417628 Selaginella moellendorffii 431  
92610 D8RFU1 PAC:15419865 Selaginella moellendorffii 257  
92605 D8RFB6 PAC:15419844 Selaginella moellendorffii 155  
92589 D8RG67 PAC:15419279 Selaginella moellendorffii 361  
92565 D8RFH2 PAC:15419224 Selaginella moellendorffii 307  
92949 D8RF76 PAC:15422120 Selaginella moellendorffii 303  
92825 D8RFD6 PAC:15421313 Selaginella moellendorffii 169  
92782 D8RGC2 PAC:15420786 Selaginella moellendorffii 857  
93022 D8RFY8 PAC:15418243 Selaginella moellendorffii 284  
71865 D8T9I1 PAC:15404094 Selaginella moellendorffii 175  
135281 D8T9U1 PAC:15412749 Selaginella moellendorffii 698  
13472 D8RGE2 PAC:15408399 Selaginella moellendorffii 332  
36412 D8RGE8 PAC:15409175 Selaginella moellendorffii 219  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9482716
            7667876
            1882418
            14659697
            10361086
            11551174