Protein Domain : IPR019568

Type:  Domain Name:  Rapsyn, myristoylation/linker region, N-terminal
Description:  Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn (receptor-associated protein of the synapse) is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction (NMJ) and is essential for the formation of synaptic acetylcholine receptor aggregates. It is required for anchoring and stabilising the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the NMJ []. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane []. Short Name:  Rapsyn_myristoylation/link_N
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0 Child Features

2 Contains

DB identifier Type Name
IPR019734 Repeat Tetratricopeptide repeat
IPR018293 Conserved_site 43kDa postsynaptic, conserved site

1 Cross References

Identifier
PF10579

2 Found Ins

DB identifier Type Name
IPR011990 Domain Tetratricopeptide-like helical domain
IPR001237 Family 43kDa postsynaptic protein

3 GO Annotations

GO Term Gene Name
GO:0033130 IPR019568
GO:0043495 IPR019568
GO:0007268 IPR019568

3 Ontology Annotations

GO Term Gene Name
GO:0033130 IPR019568
GO:0043495 IPR019568
GO:0007268 IPR019568

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15730871
            19344765