Protein Domain : IPR013026

Type:  Domain Name:  Tetratricopeptide repeat-containing domain
Description:  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed that TPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within a single TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface is contributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B. Short Name:  TPR-contain_dom
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0 Child Features

6 Contains

DB identifier Type Name
IPR013105 Repeat Tetratricopeptide repeat 2
IPR001440 Repeat Tetratricopeptide repeat 1
IPR011717 Repeat Tetratricopeptide TPR-4
IPR019544 Domain Tetratricopeptide, SHNi-TPR domain
IPR011716 Repeat Tetratricopeptide TPR-3
IPR015792 Repeat Kinesin light chain repeat

1 Cross References

Identifier
PS50293

17 Found Ins

DB identifier Type Name
IPR011990 Domain Tetratricopeptide-like helical domain
IPR021183 Family N-terminal acetyltransferase A, auxiliary subunit
IPR002151 Family Kinesin light chain
IPR013360 Family Pilus biogenesis/stability type IV, PilW
IPR016379 Family Type III secretion system, low calcium response, chaperone LcrH/SycD, subgroup
IPR005415 Family Type III secretion system, low calcium response, chaperone LcrH/SycD
IPR014162 Domain Tol-Pal system, YbgF
IPR016684 Family Type III secretion system chaperone, YscY
IPR016931 Family Uncharacterised conserved protein UCP029658, TPR
IPR014266 Family PEP-CTERM system TPR-repeat lipoprotein, putative
IPR014562 Family Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing
IPR014596 Family Uncharacterised conserved protein UCP035836
IPR014460 Family Signal transduction response regulator, predicted, VieB
IPR001237 Family 43kDa postsynaptic protein
IPR005687 Family Mitochondrial outer membrane translocase complex, subunit Tom70
IPR011236 Family Serine/threonine protein phosphatase 5
IPR003921 Family Cellulose synthase, subunit C

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR013026

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR013026

0 Parent Features

53644 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134715 D8T911 PAC:15413529 Selaginella moellendorffii 460  
440903 D8RF87 PAC:15408619 Selaginella moellendorffii 421  
92589 D8RG67 PAC:15419279 Selaginella moellendorffii 361  
92782 D8RGC2 PAC:15420786 Selaginella moellendorffii 857  
430679 D8TA55 PAC:15421570 Selaginella moellendorffii 1229  
171422 D8RGW7 PAC:15408852 Selaginella moellendorffii 586  
31230 D8RGK0 PAC:15415467 Selaginella moellendorffii 477  
411103 D8RGL0 PAC:15406167 Selaginella moellendorffii 860  
61985 D8RHP3 PAC:15420136 Selaginella moellendorffii 408  
137150 D8TD01 PAC:15417754 Selaginella moellendorffii 570  
431495 D8TCU6 PAC:15422993 Selaginella moellendorffii 442  
172051 D8RJT6 PAC:15408779 Selaginella moellendorffii 966  
10032 D8RLI5 PAC:15418905 Selaginella moellendorffii 1145  
412433 D8RLH2 PAC:15411553 Selaginella moellendorffii 721  
412442 D8RLI1 PAC:15411577 Selaginella moellendorffii 404  
412712 D8RL88 PAC:15413853 Selaginella moellendorffii 435  
412702 D8RL78 PAC:15413814 Selaginella moellendorffii 140  
96734 D8RLL8 PAC:15410080 Selaginella moellendorffii 581  
413060 D8RN78 PAC:15411480 Selaginella moellendorffii 305  
141454 D8QWC5 PAC:15409677 Selaginella moellendorffii 131  
404439 D8QVB9 PAC:15410206 Selaginella moellendorffii 689  
438124 D8QU90 PAC:15418821 Selaginella moellendorffii 365  
438270 D8QVI4 PAC:15419699 Selaginella moellendorffii 1912  
78782 D8QW65 PAC:15401585 Selaginella moellendorffii 742  
79168 D8QUI0 PAC:15422117 Selaginella moellendorffii 695  
441968 D8RP84 PAC:15411801 Selaginella moellendorffii 478  
98323 D8RPD5 PAC:15412829 Selaginella moellendorffii 404  
99084 PAC:15413642 Selaginella moellendorffii 835  
99680 D8RQX3 PAC:15418172 Selaginella moellendorffii 381  
442275 D8RS61 PAC:15409353 Selaginella moellendorffii 707  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9482716
            7667876
            1882418
            14659697