| Type: | Domain | Name: | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Description: | Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) []. Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, has been shown [] to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain. | Short Name: | PE/DAG-bd |
| DB identifier | Type | Name |
|---|---|---|
| IPR014375 | Family | Protein kinase C, alpha/beta/gamma types |
| IPR020454 | Domain | Diacylglycerol/phorbol-ester binding |
| IPR014376 | Family | Protein kinase C, delta/epsilon/eta/theta types |
| IPR020684 | Family | Rho-associated protein kinase 1/2 |
| IPR015727 | Family | Protein kinase C mu-related |
| IPR012233 | Family | Protein kinase C |
| IPR017405 | Family | Citron Rho-interacting kinase |
| IPR017356 | Family | N-chimaerin |
| IPR015721 | Family | Rho GTP exchange factor |
