Protein Domain : IPR028395

Type:  Family Name:  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Description:  Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [, ].PLC-zeta is a sperm-specific isoform of PLC that triggers Ca2+ oscillations and egg activation [, , , ]. This entry represents PLC-zeta-1. Short Name:  PLC-zeta1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10336:SF29

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004629 IPR028395
GO:0006816 IPR028395
GO:0007343 IPR028395
GO:0005829 IPR028395

4 Ontology Annotations

GO Term Gene Name
GO:0004629 IPR028395
GO:0006816 IPR028395
GO:0007343 IPR028395
GO:0005829 IPR028395

1 Parent Features

DB identifier Type Name
IPR001192 Family Phosphoinositide phospholipase C family

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15140260
            15702972
            12416999
            12117804
            15047934
            18322275