1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR016279 | Family | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma |
| Type: | Family | Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
| Description: | Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.PLC-gamma-1 may have a role in actin reorganisation and cell migration []. | Short Name: | PLC-gamma1 |
| DB identifier | Type | Name |
|---|---|---|
| IPR016279 | Family | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma |
