Protein Domain : IPR021181

Type:  Family Name:  Mitochondrial Rho GTPase
Description:  Mitochondrial Rho GTPase (also known as Miro-1 and Miro-2, for mitochondrial Rho) is involved in mitochondrial trafficking, most probably in the control of anterograde transport of mitochondria and their subcellular distribution []. They have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. There appears to be a role for Rho-like GTPases in mitochondrial homeostasis and apoptosis []. The Miro GTPases also have a C-terminal transmembrane domain, which confers targeting to the mitochondria. The protein interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules [].Miro is conserved from yeast to humans. In yeasts and plants, Miro plays roles in mitochondrial homeostasis, but the ability to build a complex that regulates its association to kinesin for microtubule-dependent transport probably arose in metazoans []. Short Name:  Mt_Rho_GTPase
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1 Child Features

DB identifier Type Name
IPR029506 Family Mitochondrial Rho GTPase 2

6 Contains

DB identifier Type Name
IPR002048 Domain EF-hand domain
IPR013684 Domain Mitochondrial Rho-like
IPR020860 Domain MIRO domain
IPR013567 Domain EF hand associated, type-2
IPR013566 Domain EF hand associated, type-1
IPR018247 Binding_site EF-Hand 1, calcium-binding site

1 Cross References

Identifier
PIRSF037488

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0003924 IPR021181
GO:0005509 IPR021181
GO:0005525 IPR021181
GO:0007005 IPR021181
GO:0005739 IPR021181
GO:0031307 IPR021181

6 Ontology Annotations

GO Term Gene Name
GO:0003924 IPR021181
GO:0005509 IPR021181
GO:0005525 IPR021181
GO:0007005 IPR021181
GO:0005739 IPR021181
GO:0031307 IPR021181

1 Parent Features

DB identifier Type Name
IPR001806 Family Small GTPase superfamily

884 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
173355 D8RQC7 PAC:15414147 Selaginella moellendorffii 640  
evm.model.supercontig_48.43 PAC:16420902 Carica papaya 650  
evm.model.supercontig_52.32 PAC:16422054 Carica papaya 646  
29647.m002094 B9S433 PAC:16804738 Ricinus communis 644  
Cucsa.084540.1 A0A0A0K5P6 PAC:16956550 Cucumis sativus 641  
Cucsa.091540.1 PAC:16957484 Cucumis sativus 648  
Cucsa.091540.2 A0A0A0LIM9 PAC:16957485 Cucumis sativus 647  
orange1.1g005908m A0A067FMY5 PAC:18093232 Citrus sinensis 670  
orange1.1g006490m A0A067FZ84 PAC:18093233 Citrus sinensis 643  
orange1.1g008223m A0A067EMM5 PAC:18134781 Citrus sinensis 573  
orange1.1g008219m A0A067EMM5 PAC:18134782 Citrus sinensis 573  
AT3G63150.1 F4J0W4 PAC:19663362 Arabidopsis thaliana 643  
AT5G27540.2 Q8RXF8 PAC:19666278 Arabidopsis thaliana 648  
AT5G27540.1 Q8RXF8 PAC:19666277 Arabidopsis thaliana 648  
AT3G05310.1 Q9MA88 PAC:19660537 Arabidopsis thaliana 648  
Thhalv10020270m V4M0E8 PAC:20183594 Eutrema salsugineum 644  
Thhalv10005831m V4LMQ5 PAC:20190797 Eutrema salsugineum 645  
Thhalv10003792m V4K402 PAC:20199088 Eutrema salsugineum 650  
Thhalv10003794m V4K402 PAC:20199087 Eutrema salsugineum 650  
Thhalv10003795m V4K402 PAC:20199086 Eutrema salsugineum 650  
Thhalv10003793m V4K402 PAC:20199085 Eutrema salsugineum 650  
Ciclev10000541m V4SFW4 PAC:20788888 Citrus clementina 649  
Ciclev10000545m V4SFW4 PAC:20788889 Citrus clementina 649  
Ciclev10000540m V4SFW4 PAC:20788890 Citrus clementina 649  
Ciclev10019250m V4U580 PAC:20811359 Citrus clementina 643  
Lus10029934 PAC:23159874 Linum usitatissimum 658  
Lus10042575 PAC:23182061 Linum usitatissimum 646  
Lus10004474 PAC:23169682 Linum usitatissimum 665  
Lus10031508 PAC:23156008 Linum usitatissimum 657  
Lus10015186 PAC:23149604 Linum usitatissimum 656  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12482879
            16630562
            21131095