| Type: | Family | Name: | Mitochondrial Rho GTPase 2 |
| Description: | Mitochondrial Rho GTPase (also known as Miro-1 and Miro-2, for mitochondrial Rho) is involved in mitochondrial trafficking, most probably in the control of anterograde transport of mitochondria and their subcellular distribution []. They have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. There appears to be a role for Rho-like GTPases in mitochondrial homeostasis and apoptosis []. The Miro GTPases also have a C-terminal transmembrane domain, which confers targeting to the mitochondria. The protein interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules [].This entry represents Miro-2 []. | Short Name: | Rho_GTPase_2 |
