Protein Domain : IPR001217

Type:  Family Name:  Transcription factor STAT
Description:  The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus []. Binding of these factors to cell-surface receptors leads to receptor autophosphorylation at a tyrosine, the phosphotyrosine being recognised by the STAT SH2 domain, which mediates the recruitment of STAT proteins from the cytosol and their association with the activated receptor. The STAT proteins are then activated by phosphorylation via members of the JAK family of protein kinases, causing them to dimerise and translocated to the nucleus, where they bind to specific promoter sequences in target genes. In mammals, STATs comprise a family of seven structurally and functionally related proteins: Stat1, Stat2, Stat3, Stat4, Stat5a and Stat5b, Stat6. STAT proteins play a critical role in regulating innate and acquired host immune responses. Dysregulation of at least two STAT signalling cascades (i.e. Stat3 and Stat5) is associated with cellular transformation.Signalling through the JAK/STAT pathway is initiated when a cytokine binds to its corresponding receptor. This leads to conformational changes in the cytoplasmic portion of the receptor, initiating activation of receptor associated members of the JAK family of kinases. The JAKs, in turn, mediate phosphorylation at the specific receptor tyrosine residues, which then serve as docking sites for STATs and other signalling molecules. Once recruited to the receptor, STATs also become phosphorylated by JAKs, on a single tyrosine residue. Activated STATs dissociate from the receptor, dimerise, translocate to the nucleus and bind to members of the GAS (gamma activated site) family of enhancers.The seven STAT proteins identified in mammals range in size from 750 and 850 amino acids. The chromosomal distribution of these STATs, as well as the identification of STATs in more primitive eukaryotes, suggest that this family arose from a single primordial gene. STATs share structurally and functionally conserved domains including: an N-terminal domain that strengthens interactions between STAT dimers on adjacent DNA-binding sites; a coiled-coil STAT domain that is implicated in protein-protein interactions; a DNA-binding domain with an immunoglobulin-like fold similar to p53 tumour suppressor protein; an EF-hand-like linker domain connecting the DNA-binding and SH2 domains; an SH2 domain () that acts as a phosphorylation-dependent switch to control receptor recognition and DNA-binding; and a C-terminal transactivation domain []. The crystal structure of the N terminus of Stat4 reveals a dimer. The interface of this dimer is formed by a ring-shaped element consisting of five short helices. Several studies suggest that this N-terminal dimerisation promotes cooperativity of binding to tandem GAS elements and with the transcriptional coactivator CBP/p300. Short Name:  STAT
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1 Child Features

DB identifier Type Name
IPR029839 Family Signal transducer and activator of transcription 4

6 Contains

DB identifier Type Name
IPR011992 Domain EF-hand domain pair
IPR000980 Domain SH2 domain
IPR013799 Domain STAT transcription factor, protein interaction
IPR012345 Domain STAT transcription factor, DNA-binding, subdomain
IPR013801 Domain STAT transcription factor, DNA-binding
IPR022752 Domain Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal

1 Cross References

Identifier
PTHR11801

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003700 IPR001217
GO:0004871 IPR001217
GO:0006355 IPR001217
GO:0007165 IPR001217
GO:0005634 IPR001217

5 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR001217
GO:0004871 IPR001217
GO:0006355 IPR001217
GO:0007165 IPR001217
GO:0005634 IPR001217

0 Parent Features

604 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
84550 D8R3X9 PAC:15417831 Selaginella moellendorffii 628  
evm.model.supercontig_77.65 PAC:16426124 Carica papaya 661  
29989.m000421 B9SR64 PAC:16815198 Ricinus communis 698  
Cucsa.058070.1 A0A0A0L1Y6 PAC:16954616 Cucumis sativus 710  
orange1.1g006526m PAC:18103149 Citrus sinensis 642  
orange1.1g006509m PAC:18103148 Citrus sinensis 642  
orange1.1g005861m PAC:18103147 Citrus sinensis 673  
AT1G17040.2 F4I632 PAC:19657147 Arabidopsis thaliana 651  
AT1G17040.1 B5X561 PAC:19657148 Arabidopsis thaliana 641  
AT1G78540.2 F4IA94 PAC:19656264 Arabidopsis thaliana 696  
AT1G78540.1 Q56XZ1 PAC:19656265 Arabidopsis thaliana 668  
Thhalv10006979m V4KYL3 PAC:20187498 Eutrema salsugineum 681  
Thhalv10018251m V4KJ31 PAC:20192143 Eutrema salsugineum 649  
Ciclev10019120m V4U062 PAC:20806539 Citrus clementina 693  
Lus10013716 PAC:23169087 Linum usitatissimum 704  
Lus10005584 PAC:23139667 Linum usitatissimum 702  
Potri.001G380900.1 A0A2K2CAA6 PAC:27047393 Populus trichocarpa 706  
Potri.001G380900.2 PAC:27047394 Populus trichocarpa 642  
Potri.011G102100.1 A0A2K1YI63 PAC:27001720 Populus trichocarpa 706  
Gorai.007G332400.2 A0A0D2TQR1 PAC:26779784 Gossypium raimondii 685  
Gorai.007G332400.1 A0A0D2R3E9 PAC:26779783 Gossypium raimondii 708  
Gorai.007G332400.3 A0A0D2SUT3 PAC:26779785 Gossypium raimondii 627  
Thecc1EG032181t1 A0A061FGJ1 PAC:27444801 Theobroma cacao 708  
Thecc1EG032181t2 A0A061F892 PAC:27444802 Theobroma cacao 693  
Thecc1EG032181t5 A0A061F9K4 PAC:27444803 Theobroma cacao 691  
Thecc1EG032181t3 A0A061F973 PAC:27444800 Theobroma cacao 720  
Thecc1EG032181t4 A0A061FA40 PAC:27444804 Theobroma cacao 581  
Migut.M00685.1.p PAC:28949864 Mimulus guttatus 690  
Araha.2449s0002.1.p PAC:28852821 Arabidopsis halleri 678  
Araha.16220s0008.1.p PAC:28860957 Arabidopsis halleri 668  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12039028
            9630226