Protein Domain : IPR016344

Type:  Family Name:  Dystrophin
Description:  Dystrophin anchors the extracellular matrix to the cytoskeleton via F-actin and is a ligand for dystroglycan. It is a component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilising the sarcolemma [, ].Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), which is the most common form of muscular dystrophy and a sex-linked recessive disorder []. Short Name:  Dystrophin
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0 Child Features

9 Contains

DB identifier Type Name
IPR011992 Domain EF-hand domain pair
IPR001202 Domain WW domain
IPR001715 Domain Calponin homology domain
IPR000433 Domain Zinc finger, ZZ-type
IPR018159 Repeat Spectrin/alpha-actinin
IPR002017 Repeat Spectrin repeat
IPR015153 Domain EF-hand domain, type 1
IPR015154 Domain EF-hand domain, type 2
IPR001589 Conserved_site Actinin-type actin-binding domain, conserved site

1 Cross References

Identifier
PIRSF002341

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0002162 IPR016344
GO:0003779 IPR016344
GO:0005200 IPR016344
GO:0016203 IPR016344

4 Ontology Annotations

GO Term Gene Name
GO:0002162 IPR016344
GO:0003779 IPR016344
GO:0005200 IPR016344
GO:0016203 IPR016344

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11917091
            16710609
            3319190