Protein Domain : IPR000795

Type:  Domain Name:  Transcription factor, GTP-binding domain
Description:  The translational GTPases are the Bacteria elongation factors, EFTu, EFG, and the initiation factor, IF2, and their archaeal homologues, the EF1, EF2, aeIF5b and aeIF2. They all contain two homologous N-terminal domains: a GTPase or G-domain, followed by an OB-domain. These translational proteins' G-domains are both structurally and functionally related to a larger family of GTPase G proteins [].In both prokaryotes and eukaryotes, there are three distinct types of elongation factors, EF-1alpha (EF-Tu), which binds GTP and an aminoacyl-tRNAand delivers the latter to the A site of ribosomes; EF-1beta (EF-Ts), which interacts with EF-1a/EF-Tu to displace GDP and thus allows the regeneration of GTP-EF-1a; and EF-2 (EF-G), which binds GTP and peptidyl-tRNA and translocates the latter from the A site to the P site. In EF-1-alpha, a specific region has been shown [] to be involved in a conformational change mediated by the hydrolysis of GTP to GDP. This region is conserved in both EF-1alpha/EF-Tu as well as EF-2/EF-G and thus seems typical for GTP-dependent proteins which bind non-initiator tRNAs to the ribosome. The GTP-binding protein synthesis factor family also includes the eukaryotic peptide chain release factor GTP-binding subunits [] and prokaryotic peptide chain release factor 3 (RF-3) []; the prokaryotic GTP-binding protein lepA and its homologue in yeast(GUF1) and Caenorhabditis elegans(ZK1236.1); yeast HBS1 []; rat statin S1 []; and the prokaryotic selenocysteine-specific elongation factor selB []. Short Name:  TF_GTP-bd_dom
Paste the following link

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PR00315
PS51722

13 Found Ins

DB identifier Type Name
IPR004539 Family Translation elongation factor EF1A, eukaryotic/archaeal
IPR006298 Family GTP-binding protein TypA
IPR004540 Family Translation elongation factor EFG/EF2
IPR000178 Family Translation initiation factor aIF-2, bacterial-like
IPR004548 Family Peptide chain release factor 3
IPR004541 Family Translation elongation factor EFTu/EF1A, bacterial/organelle
IPR006297 Family Elongation factor 4
IPR003285 Family Yeast eukaryotic release factor
IPR011779 Family Sulphate adenylyltransferase, large subunit
IPR004543 Family Translation elongation factor EFG/EF2, archaeal
IPR015760 Family Translation initiation factor IF- 2
IPR004535 Family Translation elongation factor, selenocysteine-specific
IPR022424 Family Translation initiation factor 2, gamma subunit

2 GO Annotations

GO Term Gene Name
GO:0003924 IPR000795
GO:0005525 IPR000795

2 Ontology Annotations

GO Term Gene Name
GO:0003924 IPR000795
GO:0005525 IPR000795

1 Parent Features

DB identifier Type Name
IPR005225 Domain Small GTP-binding protein domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231460 D8RFX7 PAC:15416814 Selaginella moellendorffii 982  
171512 D8RH56 PAC:15409631 Selaginella moellendorffii 447  
411087 D8RGJ4 PAC:15405592 Selaginella moellendorffii 842  
172686 D8RMF8 PAC:15413547 Selaginella moellendorffii 466  
141453 D8QWC2 PAC:15409675 Selaginella moellendorffii 694  
230099 D8QUE5 PAC:15410961 Selaginella moellendorffii 909  
148692 D8RNT4 PAC:15409458 Selaginella moellendorffii 777  
405094 D8QYD1 PAC:15410204 Selaginella moellendorffii 613  
153081 D8S6G0 PAC:15419761 Selaginella moellendorffii 397  
166557 D8QZ19 PAC:15417163 Selaginella moellendorffii 622  
230251 D8QYJ7 PAC:15412347 Selaginella moellendorffii 647  
233481 D8S9M6 PAC:15422655 Selaginella moellendorffii 393  
115313 D8SF78 PAC:15421173 Selaginella moellendorffii 469  
180460 D8SK70 PAC:15413328 Selaginella moellendorffii 661  
143627 D8R4J4 PAC:15417020 Selaginella moellendorffii 683  
230720 D8R4C2 PAC:15416134 Selaginella moellendorffii 628  
407721 D8R6J4 PAC:15421124 Selaginella moellendorffii 639  
270693 D8RAR5 PAC:15421849 Selaginella moellendorffii 447  
169717 D8RAS1 PAC:15404946 Selaginella moellendorffii 447  
437623 D8QNG7 PAC:15419724 Selaginella moellendorffii 1009  
403693 D8QS81 PAC:15408858 Selaginella moellendorffii 833  
145812 D8RC44 PAC:15402021 Selaginella moellendorffii 572  
evm.model.supercontig_103.46 PAC:16404931 Carica papaya 338  
evm.model.supercontig_14.30 PAC:16408776 Carica papaya 428  
evm.model.supercontig_16.190 PAC:16410041 Carica papaya 464  
evm.model.supercontig_21.188 PAC:16413467 Carica papaya 1037  
evm.model.supercontig_229.4 PAC:16414129 Carica papaya 1017  
evm.model.supercontig_23.2 PAC:16414227 Carica papaya 571  
evm.model.supercontig_29.106 PAC:16416129 Carica papaya 787  
evm.model.supercontig_3.424 PAC:16416729 Carica papaya 329  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3126836
            1394434
            7556078
            1709933
            7737996
            2531290
            11916378