3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0003747 | IPR003285 |
| GO:0005525 | IPR003285 |
| GO:0006415 | IPR003285 |
| Type: | Family | Name: | Yeast eukaryotic release factor |
| Description: | Elongation factors belong to a family of proteins that promote the GTP-dependent binding of aminoacyl tRNA to the A site of ribosomes during protein biosynthesis, and catalyse the translocation of thesynthesised protein chain from the A to the P site. The proteins are all relatively similar in the vicinity of their C-termini, and are also highly similar to a range of proteins that includes the nodulation Q protein fromRhizobium meliloti(Sinorhizobium meliloti), bacterial tetracycline resistance proteins [] and yeast elongation factors.Although the yeast elongation factors, or omnipotent suppressor proteins, share a large degree of similarity with other eukaryotic elongation factors,the chief difference is that they possess an N-terminal extension rich in repetitive, glutamine-rich elements, and a central charged unit.Saccharomyces cerevisiaeERF2 expression has been shown to cause non- mendelian (all progeny to the first and second generation exhibit thephenotype) inheritance of nonsense suppression (stop-codon read-through), mediated by the N-terminal and charged regions. This observation has led tothe hypothesis that the yeast elongation factors are yeast prions', showing the same properties as those theorised to exist in mammalianprions []. | Short Name: | Yeast_ERF |
| GO Term | Gene Name |
|---|---|
| GO:0003747 | IPR003285 |
| GO:0005525 | IPR003285 |
| GO:0006415 | IPR003285 |
