Protein Domain : IPR004161

Type:  Domain Name:  Translation elongation factor EFTu/EF1A, domain 2
Description:  Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [, , ]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.EF1A (also known as EF-1alpha or EF-Tu) is a G-protein. It forms a ternary complex of EF1A-GTP-aminoacyltRNA. The binding of aminoacyl-tRNA stimulates GTP hydrolysis by EF1A, causing a conformational change in EF1A that causes EF1A-GDP to detach from the ribosome, leaving the aminoacyl-tRNA attached at the A-site. Only the cognate aminoacyl-tRNA can induce the required conformational change in EF1A through its tight anticodon-codon binding [, ]. EF1A-GDP is returned to its active state, EF1A-GTP, through the action of another elongation factor, EF1B (also known as EF-Ts or EF-1beta/gamma/delta).EF1A consists of three structural domains. This entry represents domain 2 of EF2, which adopts a beta-barrel structure, and is involved in binding to both charged tRNA []. This domain is structurally related to the C-terminal domain of EF2 (), to which it displays weak sequence matches. This domain is also found in other proteins such as translation initiation factor IF-2 and tetracycline-resistance proteins. Short Name:  Transl_elong_EFTu/EF1A_2
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03144

14 Found Ins

DB identifier Type Name
IPR004539 Family Translation elongation factor EF1A, eukaryotic/archaeal
IPR006298 Family GTP-binding protein TypA
IPR004540 Family Translation elongation factor EFG/EF2
IPR000178 Family Translation initiation factor aIF-2, bacterial-like
IPR004548 Family Peptide chain release factor 3
IPR004541 Family Translation elongation factor EFTu/EF1A, bacterial/organelle
IPR006297 Family Elongation factor 4
IPR003285 Family Yeast eukaryotic release factor
IPR011779 Family Sulphate adenylyltransferase, large subunit
IPR004544 Family Translation initiation factor aIF-2, archaea
IPR004543 Family Translation elongation factor EFG/EF2, archaeal
IPR015760 Family Translation initiation factor IF- 2
IPR004535 Family Translation elongation factor, selenocysteine-specific
IPR022424 Family Translation initiation factor 2, gamma subunit

1 GO Annotation

GO Term Gene Name
GO:0005525 IPR004161

1 Ontology Annotations

GO Term Gene Name
GO:0005525 IPR004161

1 Parent Features

DB identifier Type Name
IPR009000 Domain Translation protein, beta-barrel domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231460 D8RFX7 PAC:15416814 Selaginella moellendorffii 982  
171512 D8RH56 PAC:15409631 Selaginella moellendorffii 447  
411087 D8RGJ4 PAC:15405592 Selaginella moellendorffii 842  
172686 D8RMF8 PAC:15413547 Selaginella moellendorffii 466  
141453 D8QWC2 PAC:15409675 Selaginella moellendorffii 694  
230099 D8QUE5 PAC:15410961 Selaginella moellendorffii 909  
405094 D8QYD1 PAC:15410204 Selaginella moellendorffii 613  
153081 D8S6G0 PAC:15419761 Selaginella moellendorffii 397  
166557 D8QZ19 PAC:15417163 Selaginella moellendorffii 622  
233481 D8S9M6 PAC:15422655 Selaginella moellendorffii 393  
115313 D8SF78 PAC:15421173 Selaginella moellendorffii 469  
180460 D8SK70 PAC:15413328 Selaginella moellendorffii 661  
143627 D8R4J4 PAC:15417020 Selaginella moellendorffii 683  
407721 D8R6J4 PAC:15421124 Selaginella moellendorffii 639  
270693 D8RAR5 PAC:15421849 Selaginella moellendorffii 447  
169717 D8RAS1 PAC:15404946 Selaginella moellendorffii 447  
437623 D8QNG7 PAC:15419724 Selaginella moellendorffii 1009  
403693 D8QS81 PAC:15408858 Selaginella moellendorffii 833  
evm.model.supercontig_16.190 PAC:16410041 Carica papaya 464  
evm.model.supercontig_21.188 PAC:16413467 Carica papaya 1037  
evm.model.supercontig_218.3 PAC:16413826 Carica papaya 488  
evm.model.supercontig_29.106 PAC:16416129 Carica papaya 787  
evm.model.supercontig_3.423 PAC:16416728 Carica papaya 250  
evm.model.supercontig_30.49 PAC:16416998 Carica papaya 478  
evm.model.supercontig_37.74 PAC:16418749 Carica papaya 382  
evm.model.supercontig_53.41 PAC:16422265 Carica papaya 447  
evm.model.supercontig_7.82 PAC:16425247 Carica papaya 894  
evm.model.supercontig_81.68 PAC:16426985 Carica papaya 433  
evm.model.supercontig_9.120 PAC:16428003 Carica papaya 402  
evm.model.supercontig_92.30 PAC:16428599 Carica papaya 701  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12932732
            15922593
            12762045
            15680978
            12102560
            7491491