Protein Domain : IPR004548

Type:  Family Name:  Peptide chain release factor 3
Description:  Peptide chain release factor 3 increases the formation of ribosomal termination complexes and stimulates activity of RF-1 and RF-2. It binds to guanine nucleotides and has a strong preference for UGA stop codons. This translation releasing factor, RF-3 (prfC) was originally described as stop codon-independent, in contrast to peptide chain release factor 1 (RF-1, prfA) and RF-2 (prfB). RF-1 and RF-2 are closely related to each other, while RF-3 is similar to elongation factors EF-Tu and EF-G; RF-1 is active at UAA and UAG and RF-2 is active at UAA and UGA. All bacteria and organelles have RF-1. The Mycoplasmas and organelles, which translate UGA as Trp rather than as a stop codon, lack RF-2. RF-3, in contrast, seems to be rare among bacteria and is found so far only in Escherichia coliand some other gamma subdivision Proteobacteria, in Synechocystis sp.(strain PCC 6803), and in Staphylococcus aureus. Short Name:  PrfC
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0 Child Features

3 Contains

DB identifier Type Name
IPR009022 Domain Elongation factor G, III-V domain
IPR004161 Domain Translation elongation factor EFTu/EF1A, domain 2
IPR000795 Domain Transcription factor, GTP-binding domain

2 Cross Referencess

Identifier
TIGR00503
MF_00072

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005525 IPR004548
GO:0016149 IPR004548
GO:0006415 IPR004548
GO:0005737 IPR004548

4 Ontology Annotations

GO Term Gene Name
GO:0005525 IPR004548
GO:0016149 IPR004548
GO:0006415 IPR004548
GO:0005737 IPR004548

0 Parent Features

18 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
405094 D8QYD1 PAC:15410204 Selaginella moellendorffii 613  
45670 C1MVW0 PAC:27340793 Micromonas pusilla CCMP1545 552  
107067 C1EC11 PAC:27401411 Micromonas sp RCC299 561  
Araha.11756s0220.1.p PAC:28856403 Arabidopsis halleri 531  
Sphfalx0040s0051.1.p PAC:32624107 Sphagnum fallax 695  
Pp3c22_3310V3.1.p A0A2K1IM39 PAC:32903118 Physcomitrium patens 699  
Pp3c22_3310V3.2.p A0A2K1IM39 PAC:32903119 Physcomitrium patens 699  
Mapoly0032s0082.1.p A0A2R6X712 PAC:33011595 Marchantia polymorpha 683  
Pum0072s0005.1.p A0A1X6PFM1 PAC:38007154 Porphyra umbilicalis 665  
Sphmag06G127700.1.p PAC:41921531 Sphagnum magellanicum 693  
Sphfalx06G123300.1.p PAC:41972985 Sphagnum fallax 695  
CepurR40.8G036100.1.p PAC:42991769 Ceratodon purpureus R40 685  
CepurGG1.8G035500.1.p PAC:43045513 Ceratodon purpureus GG1 685  
Thupl.29379831s0011.1.p PAC:44940738 Thuja plicata 475  
Ceric.07G027900.1.p PAC:50626329 Ceratopteris richardii 643  
Ceric.07G027900.2.p PAC:50626330 Ceratopteris richardii 478  
Ceric.07G027900.3.p PAC:50626331 Ceratopteris richardii 427  
Vocar.0024s0162.1.p PAC:32890331 Volvox carteri 654  

0 Publications