Protein Domain : IPR004541

Type:  Family Name:  Translation elongation factor EFTu/EF1A, bacterial/organelle
Description:  Translation elongation factors are responsible for two main processes during protein synthesis on the ribosome [, , ]. EF1A (or EF-Tu) is responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome. EF2 (or EF-G) is responsible for the translocation of the peptidyl-tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind. Elongation factors are responsible for achieving accuracy of translation and both EF1A and EF2 are remarkably conserved throughout evolution.EF1A (also known as EF-1alpha or EF-Tu) is a G-protein. It forms a ternary complex of EF1A-GTP-aminoacyltRNA. The binding of aminoacyl-tRNA stimulates GTP hydrolysis by EF1A, causing a conformational change in EF1A that causes EF1A-GDP to detach from the ribosome, leaving the aminoacyl-tRNA attached at the A-site. Only the cognate aminoacyl-tRNA can induce the required conformational change in EF1A through its tight anticodon-codon binding [, ]. EF1A-GDP is returned to its active state, EF1A-GTP, through the action of another elongation factor, EF1B (also known as EF-Ts or EF-1beta/gamma/delta).This entry represents EF1A (or EF-Tu) proteins found primarily in bacteria, mitochondria and chloroplasts. Eukaryotic and archaeal EF1A () are excluded from this entry. When bound to GTP, EF-Tu can form a complex with any (correctly) aminoacylated tRNA except those for initiation and for selenocysteine, in which case EF-Tu is replaced by other factors []. Short Name:  Transl_elong_EFTu/EF1A_bac/org
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0 Child Features

5 Contains

DB identifier Type Name
IPR004161 Domain Translation elongation factor EFTu/EF1A, domain 2
IPR000795 Domain Transcription factor, GTP-binding domain
IPR009000 Domain Translation protein, beta-barrel domain
IPR009001 Domain Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
IPR004160 Domain Translation elongation factor EFTu/EF1A, C-terminal

2 Cross Referencess

Identifier
TIGR00485
MF_00118_B

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003746 IPR004541
GO:0005525 IPR004541
GO:0006414 IPR004541
GO:0005622 IPR004541

4 Ontology Annotations

GO Term Gene Name
GO:0003746 IPR004541
GO:0005525 IPR004541
GO:0006414 IPR004541
GO:0005622 IPR004541

0 Parent Features

889 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
153081 D8S6G0 PAC:15419761 Selaginella moellendorffii 397  
233481 D8S9M6 PAC:15422655 Selaginella moellendorffii 393  
evm.model.supercontig_30.49 PAC:16416998 Carica papaya 478  
29703.m001548 B9SFP0 PAC:16806244 Ricinus communis 449  
Cucsa.084920.1 A0A0A0K909 PAC:16956612 Cucumis sativus 450  
Cucsa.196490.1 PAC:16968272 Cucumis sativus 482  
orange1.1g011581m A0A067FTF8 PAC:18132568 Citrus sinensis 482  
orange1.1g013007m A0A067G042 PAC:18093165 Citrus sinensis 451  
AT4G02930.1 Q9ZT91 PAC:19644169 Arabidopsis thaliana 454  
AT4G20360.1 P17745 PAC:19648263 Arabidopsis thaliana 476  
Thhalv10025053m V4MQE5 PAC:20194762 Eutrema salsugineum 484  
Thhalv10000869m V4LIE0 PAC:20202604 Eutrema salsugineum 480  
Thhalv10028652m V4MZA3 PAC:20198072 Eutrema salsugineum 451  
Thhalv10028651m V4L6P6 PAC:20198071 Eutrema salsugineum 452  
Thhalv10007606m V4MWB0 PAC:20185291 Eutrema salsugineum 452  
Ciclev10019924m V4TNE8 PAC:20809139 Citrus clementina 483  
Ciclev10020118m V4U5D0 PAC:20810947 Citrus clementina 450  
Lus10041946 PAC:23153804 Linum usitatissimum 488  
Lus10027995 PAC:23181176 Linum usitatissimum 495  
Lus10043342 PAC:23168151 Linum usitatissimum 484  
Lus10008161 PAC:23173787 Linum usitatissimum 564  
Lus10017957 PAC:23147921 Linum usitatissimum 1020  
Lus10019493 PAC:23181559 Linum usitatissimum 376  
Potri.014G138100.3 PAC:27033306 Populus trichocarpa 353  
Potri.014G138100.2 PAC:27033305 Populus trichocarpa 372  
Potri.014G138100.1 B9IA13 PAC:27033304 Populus trichocarpa 450  
Potri.001G110200.1 B9GKN8 PAC:27048096 Populus trichocarpa 483  
Potri.002G215900.1 A0A2K2BMF5 PAC:27023547 Populus trichocarpa 447  
Potri.003G121600.1 B9GW65 PAC:27000107 Populus trichocarpa 483  
Gorai.003G115000.1 A0A0D2QJ53 PAC:26798874 Gossypium raimondii 466  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12932732
            15922593
            12762045
            15680978
            12102560
            16213500