Protein Domain : IPR012337

Type:  Domain Name:  Ribonuclease H-like domain
Description:  The catalytic domain of several polynucleotidyl transferases share a similar structure, consisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets, suggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII), HIV RNase (reverse transcriptase domain), retroviral integrase (catalytic domain), Mu transposase (core domain), transposase inhibitor Tn5 (containing additional all-alpha subdomains), DnaQ-like 3'-5' exonucleases (exonuclease domains), RuvC resolvase, and mitochondrial resolvase ydc2 (catalytic domain) [, , ]. Short Name:  RNaseH-like_dom
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12 Child Features

DB identifier Type Name
IPR002156 Domain Ribonuclease H domain
IPR013520 Domain Exonuclease, RNase T/DNA polymerase III
IPR006641 Domain YqgF/RNase H-like domain
IPR006133 Domain DNA-directed DNA polymerase, family B, exonuclease domain
IPR024567 Domain Ribonuclease HII/HIII domain
IPR001584 Domain Integrase, catalytic core
IPR003165 Domain Piwi domain
IPR002562 Domain 3'-5' exonuclease domain
IPR019288 Domain Predicted 3'-5' exonuclease, PolB-like
IPR015242 Domain Mitochondrial resolvase Ydc2, catalytic
IPR004189 Domain Bacteriophage Mu, transposase
IPR015361 Domain Taq polymerase, thermostable, exonuclease region

9 Contains

DB identifier Type Name
IPR006641 Domain YqgF/RNase H-like domain
IPR014737 Domain Transposase, Tn5-like, C-terminal
IPR014735 Domain Transposase, Tn5-like, N-terminal
IPR014736 Domain Transposase, Tn5-like, core
IPR003201 Domain Transposase Tn5, dimerisation
IPR013620 Domain Exonuclease C-terminal
IPR020563 Binding_site Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site
IPR013617 Domain DNA-directed DNA polymerase, family B, viral insert domain
IPR001598 Conserved_site Transposase, IS30, conserved site

2 Cross Referencess

Identifier
G3DSA:3.30.420.10
SSF53098

12 Found Ins

DB identifier Type Name
IPR002298 Family DNA polymerase A
IPR006172 Family DNA-directed DNA polymerase, family B
IPR017290 Family Ribonuclease H, bacteria
IPR018320 Family DNA polymerase 1
IPR015833 Family DNA-directed DNA polymerase, family B, mitochondrial linear plasmid
IPR006310 Family DnaQ exonuclease/DinG helicase, predicted
IPR006308 Family DNA polymerase III, alpha subunit, Gram-positive type
IPR014636 Family RNase H, phosphoglycerate mutase domain-containing
IPR017067 Family Ribonuclease H1, eukaryote
IPR006292 Family Ribonuclease D
IPR014382 Family DNA-directed DNA polymerase, family B, adenovirus
IPR002297 Family DNA-directed DNA-polymerase, family A, mitochondria

1 GO Annotation

GO Term Gene Name
GO:0003676 IPR012337

1 Ontology Annotations

GO Term Gene Name
GO:0003676 IPR012337

0 Parent Features

108964 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134781 D8T966 PAC:15413703 Selaginella moellendorffii 64  
231485 D8RG28 PAC:15416876 Selaginella moellendorffii 737  
410683 D8RFI4 PAC:15407187 Selaginella moellendorffii 312  
440920 D8RFE8 PAC:15408680 Selaginella moellendorffii 1208  
431041 D8TBC2 PAC:15419932 Selaginella moellendorffii 570  
431746 D8TDN0 PAC:15402916 Selaginella moellendorffii 187  
412061 D8RJX9 PAC:15408448 Selaginella moellendorffii 362  
412538 D8RLT1 PAC:15412303 Selaginella moellendorffii 411  
412706 D8RL82 PAC:15413821 Selaginella moellendorffii 385  
172615 D8RM96 PAC:15413399 Selaginella moellendorffii 514  
141141 D8QUP6 PAC:15407256 Selaginella moellendorffii 236  
165487 D8QUV1 PAC:15413584 Selaginella moellendorffii 169  
79010 D8QUC6 PAC:15421255 Selaginella moellendorffii 176  
98227 D8RNT3 PAC:15412065 Selaginella moellendorffii 968  
58287 D8RQB4 PAC:15405663 Selaginella moellendorffii 175  
99227 D8RQ36 PAC:15415029 Selaginella moellendorffii 848  
173603 D8RRR0 PAC:15416251 Selaginella moellendorffii 2367  
413916 D8RR15 PAC:15418230 Selaginella moellendorffii 299  
432255 D8TFG0 PAC:15402084 Selaginella moellendorffii 274  
100501 D8RS45 PAC:15423179 Selaginella moellendorffii 200  
232189 D8RS27 PAC:15417493 Selaginella moellendorffii 1002  
232193 D8RS54 PAC:15417518 Selaginella moellendorffii 1419  
442263 D8RS33 PAC:15409326 Selaginella moellendorffii 2412  
414779 D8RUL0 PAC:15419760 Selaginella moellendorffii 578  
414985 D8RU81 PAC:15421205 Selaginella moellendorffii 1200  
404837 D8QXI6 PAC:15413282 Selaginella moellendorffii 328  
104837 D8RZE6 PAC:15415070 Selaginella moellendorffii 328  
416308 D8RYV9 PAC:15422270 Selaginella moellendorffii 111  
416415 D8RZ77 PAC:15423036 Selaginella moellendorffii 300  
417131 D8S1G7 PAC:15401482 Selaginella moellendorffii 177  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8696976
            15299518
            12823554