Protein Domain : IPR006172

Type:  Family Name:  DNA-directed DNA polymerase, family B
Description:  DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most importantevents in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases () by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA, using a complementary DNA chain as a template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used for the de novosynthesis of a DNA chain. Even though there are 2 different methods of priming, these are mediated by 2 very similar polymerases classes, A and B, with similar methods of chain elongation. A number of DNA polymerases have been grouped under the designation of DNA polymerase family B.Six regions of similarity (numbered from I to VI) are found in all or a subset of the B family polymerases. The most conserved region (I) includes a conservedtetrapeptide with two aspartate residues. Its function is not yet known. However, it has been suggested [] that it may be involved in binding amagnesium ion. All sequences in the B family contain a characteristic DTDS motif, and possess many functionaldomains, including a 5'-3' elongation domain, a 3'-5' exonuclease domain [],a DNA binding domain, and binding domains for both dNTP's and pyrophosphate []. Short Name:  DNA-dir_DNA_pol_B
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5 Child Features

DB identifier Type Name
IPR030559 Family DNA polymerase zeta catalytic subunit
IPR029703 Family DNA polymerase epsilon catalytic subunit
IPR014382 Family DNA-directed DNA polymerase, family B, adenovirus
IPR014416 Family DNA-directed DNA polymerase, family B, phi29-like virus
IPR029702 Family DNA polymerase alpha catalytic subunit

9 Contains

DB identifier Type Name
IPR012337 Domain Ribonuclease H-like domain
IPR006133 Domain DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 Domain DNA-directed DNA polymerase, family B, multifunctional domain
IPR015088 Domain Zinc finger, DNA-directed DNA polymerase, family B, alpha
IPR004868 Domain DNA-directed DNA polymerase, family B, mitochondria/virus
IPR017964 Conserved_site DNA-directed DNA polymerase, family B, conserved site
IPR013617 Domain DNA-directed DNA polymerase, family B, viral insert domain
IPR013660 Domain DNA polymerase B exonuclease, N-terminal
IPR021639 Domain DNA polymerase catalytic subunit Pol, C-terminal

2 Cross Referencess

Identifier
PR00106
SM00486

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0000166 IPR006172
GO:0003676 IPR006172
GO:0003887 IPR006172

3 Ontology Annotations

GO Term Gene Name
GO:0000166 IPR006172
GO:0003676 IPR006172
GO:0003887 IPR006172

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
413713 D8RPZ7 PAC:15416663 Selaginella moellendorffii 1656  
232193 D8RS54 PAC:15417518 Selaginella moellendorffii 1419  
442263 D8RS33 PAC:15409326 Selaginella moellendorffii 2412  
155333 D8SHC6 PAC:15405375 Selaginella moellendorffii 980  
422725 D8SJC4 PAC:15420935 Selaginella moellendorffii 935  
evm.model.supercontig_32.133 PAC:16417356 Carica papaya 429  
evm.model.supercontig_42.182 PAC:16419770 Carica papaya 738  
evm.model.supercontig_48.68 PAC:16420929 Carica papaya 972  
evm.model.supercontig_55.134 PAC:16422522 Carica papaya 1546  
29791.m000536 B9SSU6 PAC:16808607 Ricinus communis 2227  
30115.m001231 B9SC90 PAC:16818010 Ricinus communis 1526  
30128.m008782 B9RF68 PAC:16818371 Ricinus communis 2066  
30156.m001758 B9RPS7 PAC:16820888 Ricinus communis 1049  
Cucsa.367180.1 A0A0A0LPU1 PAC:16981634 Cucumis sativus 1547  
Cucsa.385240.1 PAC:16982538 Cucumis sativus 969  
Cucsa.083890.1 PAC:16956486 Cucumis sativus 1080  
Cucsa.091240.1 PAC:16957433 Cucumis sativus 1378  
orange1.1g000430m A0A067GUW4 PAC:18124599 Citrus sinensis 1517  
orange1.1g000502m A0A067ER05 PAC:18134793 Citrus sinensis 1459  
orange1.1g000501m A0A067ER05 PAC:18134792 Citrus sinensis 1459  
orange1.1g000161m PAC:18119093 Citrus sinensis 1988  
orange1.1g001780m PAC:18134133 Citrus sinensis 1014  
AT5G63960.1 Q9LVN7 PAC:19666442 Arabidopsis thaliana 1095  
AT5G63960.2 F4KC69 PAC:19666441 Arabidopsis thaliana 1112  
AT5G67100.1 Q9FHA3 PAC:19670302 Arabidopsis thaliana 1524  
AT1G08260.1 F4HW04 PAC:19651556 Arabidopsis thaliana 2161  
AT1G67500.2 PAC:19653495 Arabidopsis thaliana 1916  
AT1G67500.1 Q766Z3 PAC:19653496 Arabidopsis thaliana 1890  
AT2G27120.1 F4IFN6 PAC:19639075 Arabidopsis thaliana 2138  
Thhalv10006524m V4KEA4 PAC:20187327 Eutrema salsugineum 2170  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8679562
            9757117
            2461550