| Type: | Conserved_site | Name: | DNA-directed DNA polymerase, family B, conserved site |
| Description: | DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most importantevents in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases () by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA, using a complementary DNA chain as a template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used for the de novosynthesis of a DNA chain. Even though there are 2 different methods of priming, these are mediated by 2 very similar polymerases classes, A and B, with similar methods of chain elongation. A number of DNA polymerases have been grouped under the designation of DNA polymerase family B.Six regions of similarity (numbered from I to VI) are found in all or a subset of the B family polymerases. The most conserved region (I) includes a conservedtetrapeptide with two aspartate residues. Its function is not yet known. However, it has been suggested [] that it may be involved in binding amagnesium ion. All sequences in the B family contain a characteristic DTDS motif, and possess many functionaldomains, including a 5'-3' elongation domain, a 3'-5' exonuclease domain [],a DNA binding domain, and binding domains for both dNTP's and pyrophosphate []. | Short Name: | DNA-dir_DNA_pol_B_CS |
| DB identifier | Type | Name |
|---|---|---|
| IPR006172 | Family | DNA-directed DNA polymerase, family B |
| IPR006134 | Domain | DNA-directed DNA polymerase, family B, multifunctional domain |
| IPR015833 | Family | DNA-directed DNA polymerase, family B, mitochondrial linear plasmid |
| IPR014382 | Family | DNA-directed DNA polymerase, family B, adenovirus |
| IPR014416 | Family | DNA-directed DNA polymerase, family B, phi29-like virus |
| GO Term | Gene Name |
|---|---|
| GO:0000166 | IPR017964 |
| GO:0003676 | IPR017964 |
| GO:0003887 | IPR017964 |
