Protein Domain : IPR018320

Type:  Family Name:  DNA polymerase 1
Description:  DNA carries the biological information that instructs cells how to exist in an ordered fashion. Accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA polymerases, which add nucleotide triphosphate (dNTP) residues to the 3'-end of the growing DNA chain, using a complementary DNA as template. Small RNA molecules are generally used as primers for chain elongation, although terminal proteins may also be used. DNA-dependent DNA polymerases have been grouped into families, denoted A, Band X, on the basis of sequence similarities [, ]. Members of family A, which includes bacterial and bacteriophage polymerases, share significant similarity to Escherichia colipolymerase I; hence family A is also known as the pol I family. The bacterial polymerases also contain an exonuclease activity, which is coded for in the N-terminal portion. Three motifs, A, B and C [], are seen to be conserved across all DNA polymerases, with motifs A and C also seen in RNA polymerases. They are centred on invariant residues, and their structural significance was implied from the Klenow (E. coli) structure. Motif A contains a strictly-conserved aspartate at the junction of a beta-strand and an alpha-helix; motif B contains an alpha-helix with positive charges; and motif C has a doublet of negative charges, located in a beta-turn-beta secondary structure []. Short Name:  DNA_polymerase_1
Paste the following link

0 Child Features

10 Contains

DB identifier Type Name
IPR001098 Domain DNA-directed DNA polymerase, family A, palm domain
IPR012337 Domain Ribonuclease H-like domain
IPR020045 Domain 5'-3' exonuclease, C-terminal domain
IPR008918 Conserved_site Helix-hairpin-helix motif, class 2
IPR002562 Domain 3'-5' exonuclease domain
IPR020046 Domain 5'-3' exonuclease, alpha-helical arch, N-terminal
IPR002421 Domain 5'-3' exonuclease, N-terminal
IPR003583 Domain Helix-hairpin-helix DNA-binding motif, class 1
IPR019760 Conserved_site DNA-directed DNA polymerase, family A, conserved site
IPR015361 Domain Taq polymerase, thermostable, exonuclease region

1 Cross References

Identifier
TIGR00593

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003887 IPR018320
GO:0006260 IPR018320

2 Ontology Annotations

GO Term Gene Name
GO:0003887 IPR018320
GO:0006260 IPR018320

1 Parent Features

DB identifier Type Name
IPR002298 Family DNA polymerase A

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1007219m.p PAC:33656828 Brachypodium distachyon Pangenome 419  
Brdisv1pangenome1008858m.p PAC:33620940 Brachypodium distachyon Pangenome 678  
Brdisv1pangenome1012228m.p PAC:33608037 Brachypodium distachyon Pangenome 488  
Brdisv1BdTR12c1039960m.p PAC:34404538 Brachypodium distachyon BdTR12c 892  
Brdisv1BdTR11A1047360m.p PAC:35688195 Brachypodium distachyon BdTR11a 676  
Brdisv1BdTR11A1045090m.p PAC:35691123 Brachypodium distachyon BdTR11a 678  
Brdisv1BdTR11A1042037m.p PAC:35696437 Brachypodium distachyon BdTR11a 513  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2196557
            3479792